{"doi":"10.2218/gtopdb/f45/2023.1","title":"Neuropeptide W/neuropeptide B receptors in GtoPdb v.2023.1","abstract":"<jats:p>The neuropeptide BW receptor 1 (NPBW1, provisional nomenclature [6]) is activated by two 23-amino-acid peptides, neuropeptide W (neuropeptide W-23) and neuropeptide B (neuropeptide B-23) [22, 7]. C-terminally extended forms of the peptides (neuropeptide W-30 and neuropeptide B-29) also activate NPBW1 [2]. Unique to both forms of neuropeptide B is the N-terminal bromination of the first tryptophan residue, and it is from this post-translational modification that the nomenclature NPB is derived. These peptides were first identified from bovine hypothalamus and therefore are classed as neuropeptides. Endogenous variants of the peptides without the N-terminal bromination, des-Br-neuropeptide B-23 and des-Br-neuropeptide B-29, were not found to be major components of bovine hypothalamic tissue extracts. The NPBW2 receptor is activated by the short and C-terminal extended forms of neuropeptide W and neuropeptide B [2].</jats:p>","journal":"IUPHAR/BPS Guide to Pharmacology CITE","year":2023,"id":16328,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":120927,"name":"Janet J. Maguire","orcid":"0000-0002-9254-7040","position":1,"is_corresponding":false},{"id":120928,"name":"Gurminder Singh","orcid":null,"position":2,"is_corresponding":false},{"id":120926,"name":"Anthony P. Davenport","orcid":"0000-0002-2096-3117","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21071399","pmcid":null,"openalex_id":"https://openalex.org/W4382310213","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.12588817,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-sa","oa_locations":[{"url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8694/11477","host_type":"journal"},{"url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8694/11477","host_type":"GOLD"},{"url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8694/11477","host_type":"publisher"},{"url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8694/11478","host_type":"publisher"},{"url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8694/11476","host_type":"publisher"},{"url":"http://dx.doi.org/10.2218/gtopdb/f45/2023.1","host_type":"journal"}],"fields_of_study":["Neuropeptides and Animal Physiology","Regulation of Appetite and Obesity","Receptor Mechanisms and Signaling","Biology","Medicine"],"mesh_terms":[],"keywords":["Neuropeptide","Neuropeptide Y receptor","Receptor","Chemistry","Endocrinology","Internal medicine","Biology","Biochemistry","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T21:29:14.003525Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}