{"doi":"10.2217/rme-2021-0032","title":"Novel Assessment of Leukocyte-Rich Platelet-Rich Plasma on Functional and Patient-Reported Outcomes in Knee Osteoarthritis: A Pilot Study","abstract":"Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II–III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.","journal":"Regenerative Medicine","year":2021,"id":193212,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.914,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478536,"name":"Gu Eon Kang","orcid":"0000-0002-4791-6839","position":1,"is_corresponding":false},{"id":761085,"name":"Brett Heldt","orcid":"0000-0002-5983-1381","position":2,"is_corresponding":false},{"id":761565,"name":"Olumide F. Sokunbi","orcid":null,"position":3,"is_corresponding":false},{"id":712843,"name":"Bo Song","orcid":"0000-0003-1622-1927","position":4,"is_corresponding":false},{"id":761086,"name":"Peter Yeh","orcid":"0000-0003-4862-7665","position":5,"is_corresponding":false},{"id":761566,"name":"Max Epstein","orcid":null,"position":6,"is_corresponding":false},{"id":761567,"name":"Theodore B Shybut","orcid":null,"position":7,"is_corresponding":false},{"id":249412,"name":"Brendan Lee","orcid":"0000-0001-8573-4211","position":8,"is_corresponding":false},{"id":478542,"name":"Bijan Najafi","orcid":"0000-0002-0320-8101","position":9,"is_corresponding":false},{"id":471889,"name":"Prathap Jayaram","orcid":"0000-0001-6209-5410","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T23:49:47.463744Z","pmid":"34424054","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}