{"doi":"10.2217/pgs-2021-0146","title":"<i>CYP2D6</i> Gene Resequencing in the Malagasy, a Population at the Crossroads between Asia and Africa: A Pilot Study","abstract":"Background: Plasmodium vivax malaria is endemic in Madagascar, where populations have genetic inheritance from Southeast Asia and East Africa. Primaquine, a drug of choice for vivax malaria, is metabolized principally via CYP2D6. CYP2D6 variation was characterized by locus-specific gene sequencing and was compared with TaqMan™ genotype data. Materials & methods: Long-range PCR amplicons were generated from 96 Malagasy samples and subjected to next-generation sequencing. Results: The authors observed high concordance between TaqMan™-based CYP2D6 genotype calls and the base calls from sequencing. In addition, there are new variants and haplotypes present in the Malagasy. Conclusion: Sequencing unique admixed populations provides more detailed and accurate insights regarding CYP2D6 variability, which may help optimize primaquine treatment across human genetic diversity.","journal":"Pharmacogenomics","year":2022,"id":290847,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":777029,"name":"Rajeev K. Mehlotra","orcid":"0000-0003-4205-750X","position":1,"is_corresponding":false},{"id":974192,"name":"Karim A Pirani","orcid":null,"position":2,"is_corresponding":false},{"id":451464,"name":"Arsène Ratsimbasoa","orcid":"0000-0002-6170-8577","position":3,"is_corresponding":false},{"id":48175,"name":"SCOTT M. WILLIAMS","orcid":"0000-0002-4835-9544","position":4,"is_corresponding":false},{"id":232876,"name":"Andrea Gaedigk","orcid":"0000-0001-6968-1893","position":5,"is_corresponding":false},{"id":605487,"name":"Peter A. Zimmerman","orcid":"0000-0002-5349-4513","position":6,"is_corresponding":false},{"id":247915,"name":"E. Ricky Chan","orcid":"0000-0001-9277-5329","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:34.502076Z","pmid":"35230160","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}