{"doi":"10.2217/pgs-2017-0015","title":"Serum Clomipramine and Desmethylclomipramine Levels in a CYP2C19 and CYP2D6 Intermediate Metabolizer","abstract":null,"journal":"Pharmacogenomics","year":2017,"id":608560,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1563120,"name":"Mark Schneiderhan","orcid":null,"position":1,"is_corresponding":false},{"id":562290,"name":"Seenae Eum","orcid":"0000-0003-4389-7447","position":2,"is_corresponding":false},{"id":1563121,"name":"Jeffrey R Bishop","orcid":null,"position":3,"is_corresponding":false},{"id":1563119,"name":"Jacob T Brown","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Serum Clomipramine and Desmethylclomipramine Levels in a CYP2C19 and CYP2D6 Intermediate Metabolizer","abstract":"Pharmacogenetics within psychiatry has the potential to aid in the dose and selection of medications. A substantial number of psychiatric medications are metabolized through either of the highly polymorphic drug-metabolizing enzymes CYP2D6 and CYP2C19. Of these, clomipramine is subject to metabolism by both CYP2C19 and CYP2D6, leaving individuals with deficiencies of these drug-metabolizing enzymes at risk of higher concentrations of the parent molecule. Herein, we present the case of a 29-year-old male with diagnoses of depression and obsessive compulsive disorder who had trialed and failed a dozen psychiatric medications, many of which are subject to metabolism by CYP2D6 and/or CYP2C19, and had most recently been taking clomipramine for approximately 2.5 years. Pharmacogenetic testing revealed this patient to be an intermediate metabolizer for both CYP2C19 (*1/*2) and CYP2D6 (*4/*41), which resulted in considerably elevated serum trough concentrations of clomipramine and its active metabolite desmethylclomipramine. This case provides a retrospective view of how the knowledge of an individual's pharmacogenetic test results can aid in their clinical care.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28470111","pmcid":null,"openalex_id":"https://openalex.org/W2610921663","authors":[],"funders":[{"funder_name":"NIGH","grant_id":"MH083888","title":null}],"total_grants":1,"fwci":0.5248,"citation_percentile":0.68352316,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.2217/pgs-2017-0015","host_type":"publisher"},{"url":"https://doi.org/10.2217/pgs-2017-0015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28470111","host_type":"repository"}],"fields_of_study":["Pharmacogenetics and Drug Metabolism","Schizophrenia research and treatment","Pharmacology and Obesity Treatment"],"mesh_terms":["Adult","Antidepressive Agents, Tricyclic","Clomipramine","Depressive Disorder","Humans","Male","Obsessive-Compulsive Disorder","Retrospective Studies","Cytochrome P-450 CYP2D6","Cytochrome P-450 CYP2C19"],"keywords":["Clomipramine","CYP2C19","CYP2D6","Pharmacogenetics","Pharmacology","Medicine","Metabolite","Drug","Psychology","Psychiatry","Internal medicine","Biology","Cytochrome P450","Genetics","Metabolism","Genotype","Gene","Pharmacogenomics","Desmethylclomipramine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T18:35:47.938887Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}