{"doi":"10.2217/nnm-2023-0120","title":"Lipid Nanocarrier Targeting Activated Macrophages for Antiretroviral Therapy of HIV Reservoir","abstract":"Aim: To develop lipid nano-antiretrovirals (LNAs) for the treatment of HIV-infected macrophages. Materials & methods: LNAs were prepared with docosahexaenoic acid to facilitate brain penetration and surface-decorated with folate considering that infected macrophages often overexpress folate receptors. Results: Folate-decorated LNAs loading rilpivirine (RPV) were efficiently taken up by folate receptor-expressing cell types including activated macrophages. The intracellular Cmax of the RPV-LNAs in activated macrophages was 2.54-fold and the area under the curve was 3.4-fold versus free RPV, translating to comparable or higher (p < 0.01; RPV ≤6.5 ng/ml) activities against HIV infectivity and superior protection (p < 0.05) against HIV cytotoxicity. LNAs were also effective in monocyte-derived macrophages. Conclusion: These findings demonstrate the potential of LNAs for the treatment of infected macrophages, which are key players in HIV reservoirs.","journal":"Nanomedicine","year":2023,"id":355889,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":495233,"name":"Mengjie Si","orcid":"0000-0002-5825-2089","position":1,"is_corresponding":false},{"id":323081,"name":"Hui Xue","orcid":"0000-0002-2685-2821","position":2,"is_corresponding":false},{"id":1104664,"name":"Ngoc Thi Hong Tran","orcid":null,"position":3,"is_corresponding":false},{"id":282164,"name":"Kamel Khalili","orcid":"0000-0002-6819-5217","position":4,"is_corresponding":false},{"id":282153,"name":"Rafal Kaminski","orcid":"0000-0001-8827-6658","position":5,"is_corresponding":false},{"id":323082,"name":"Ho Lun Wong","orcid":"0000-0001-5516-3497","position":6,"is_corresponding":false},{"id":495234,"name":"Di Wu","orcid":"0000-0002-3238-6388","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T01:13:21.145955Z","pmid":"37815117","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}