{"doi":"10.2217/nnm-2017-0019","title":"Using Dextran-encapsulated Gold Nanoparticles As Insulin Carriers to Prolong Insulin Activity","abstract":null,"journal":"Nanomedicine","year":2017,"id":596582,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1527957,"name":"Wen-Jie Chen","orcid":null,"position":1,"is_corresponding":false},{"id":1527958,"name":"Yu-Chie Chen","orcid":null,"position":2,"is_corresponding":false},{"id":1527956,"name":"Kai-Chieh Lee","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Using Dextran-encapsulated Gold Nanoparticles As Insulin Carriers to Prolong Insulin Activity","abstract":"Aim: Diabetes mellitus is commonly treated with painful insulin injections. We aim to explore drug carriers that can prolong insulin activity. Materials & methods: Dextran-encapsulated gold NPs (AuNPs@Dextran) that can bind with insulin are used as insulin carriers. The affinity (K d = ∼42 pM) between insulin and insulin receptors on the cells is much higher than that (K d = ∼4.02 μM) of insulin and AuNPs@Dextran. Thus, insulin released from the AuNP@Dextran–insulin conjugates to maintain kinetic equilibrium and prefers to bind to the insulin receptor. The slow release of insulin from the AuNP@Dextran–insulin conjugates facilitates the lasting of insulin activity. Results & discussion: AuNP@Dextran–insulin conjugates can prolong insulin activity to 12 h, whereas free form insulin loses activity after 4 h in adipocyte cells. Conclusion: AuNPs@Dextran are suitable carriers that can prolong insulin activity.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28703075","pmcid":null,"openalex_id":"https://openalex.org/W2735131878","authors":[],"funders":[],"total_grants":0,"fwci":0.7644,"citation_percentile":0.69690605,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":4},{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.2217/nnm-2017-0019","host_type":"publisher"},{"url":"https://doi.org/10.2217/nnm-2017-0019","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28703075","host_type":"repository"}],"fields_of_study":["Graphene and Nanomaterials Applications","Pancreatic function and diabetes","Advanced Drug Delivery Systems","3T3-L1 Cells","Animals","Dextrans","Diabetes Mellitus","Drug Carriers","Drug Discovery","Drug Liberation","Glucose","Gold","Humans","Insulin","Insulin, Long-Acting","Metal Nanoparticles","Mice","Particle Size","Receptor, Insulin","Surface Properties"],"mesh_terms":["Animals","Dextrans","Diabetes Mellitus","Drug Carriers","Glucose","Gold","Humans","Insulin","Particle Size","Receptor, Insulin","Surface Properties","3T3-L1 Cells","Insulin, Long-Acting","Mice","Metal Nanoparticles","Drug Discovery","Drug Liberation"],"keywords":["Insulin","Dextran","Chemistry","Diabetes mellitus","Internal medicine","Conjugate","Insulin receptor substrate","Insulin receptor","Endocrinology","Pharmacology","Medicine","Biochemistry","Insulin resistance","gold nanoparticles","Drug Delivery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T10:42:09.253908Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}