{"doi":"10.2217/imt-2021-0080","title":"Safety levels of systemic IL-12 induced by cDNA expression as a cancer therapeutic","abstract":"Aim: The aim of this work is to utilize a gene expression procedure to safely express systemic IL-12 and evaluate its effects in mouse tumor models. Materials & methods: Secondary lymphoid organs and tumors from EL4 and B16 tumor-bearing mice were analyzed by supervised and unsupervised methods. Results: IL-12 cDNA induced systemic IL-12 protein levels lower than the tolerated dose in patients. Control of tumor growth was observed in subcutaneous B16 and EL4 tumors. Systemic IL-12 expression induced a higher frequency of both total tumor-infiltrated CD45+ cells and proliferative IFN-γ+CD8+ T cells along with a lower frequency of CD4+FOXP3+ and CD11b+Gr-1+ cells. Conclusion: This approach characterizes the systemic effects of IL-12, helping to improve treatment of metastases or solid tumors.","journal":"Immunotherapy","year":2021,"id":207071,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9661,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":792136,"name":"María Estefania Viano","orcid":"0000-0001-5107-928X","position":1,"is_corresponding":false},{"id":792137,"name":"Natalia Soledad Baez","orcid":"0000-0002-5178-228X","position":2,"is_corresponding":false},{"id":792618,"name":"Della Reynolds","orcid":null,"position":3,"is_corresponding":false},{"id":792619,"name":"Mariana Matellon","orcid":null,"position":4,"is_corresponding":false},{"id":309027,"name":"Howard A. Young","orcid":"0000-0002-3118-5111","position":5,"is_corresponding":false},{"id":583216,"name":"María Cecilia Rodriguez‐Galán","orcid":"0000-0002-5703-3116","position":6,"is_corresponding":false},{"id":792135,"name":"Constanza Savid-Frontera","orcid":"0000-0001-8614-3528","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:51:45.688025Z","pmid":"34783257","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}