{"doi":"10.2217/epi.14.77","title":"Application of Artificial Neural Networks to Link Genetic and Environmental Factors to DNA Methylation in Colorectal Cancer","abstract":null,"journal":"Epigenomics","year":2015,"id":596018,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1526434,"name":"Enzo Grossi","orcid":null,"position":1,"is_corresponding":false},{"id":1526435,"name":"Angela Lopomo","orcid":null,"position":2,"is_corresponding":false},{"id":1526436,"name":"Roberto Spisni","orcid":null,"position":3,"is_corresponding":false},{"id":1526437,"name":"Massimo Buscema","orcid":null,"position":4,"is_corresponding":false},{"id":1526438,"name":"Lucia Migliore","orcid":null,"position":5,"is_corresponding":false},{"id":1526433,"name":"Fabio Coppedè","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Application of Artificial Neural Networks to Link Genetic and Environmental Factors to DNA Methylation in Colorectal Cancer","abstract":"AIMS: We applied artificial neural networks (ANNs) to understand the connections among polymorphisms of genes involved in folate metabolism, clinico-pathological features and promoter methylation levels of MLH1, APC, CDKN2A(INK4A), MGMT and RASSF1A in 83 sporadic colorectal cancer (CRC) tissues, and to link dietary and lifestyle factors with gene promoter methylation. MATERIALS & METHODS: Promoter methylation was assessed by means of methylation-sensitive high-resolution melting and genotyping by PCR-RFLP technique. Data were analyzed with the Auto Contractive Map, a special kind of ANN able to define the strength of the association of each variable with all the others and to visually show the map of the main connections. RESULTS: We observed a strong connection between the low methylation levels of the five CRC genes and the MTR 2756AA genotype. Several other connections were revealed, including those between dietary and lifestyle factors and the methylation levels of CRC genes. CONCLUSION: ANNs revealed the complexity of the interconnections among factors linked to DNA methylation in CRC.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25942531","pmcid":null,"openalex_id":"https://openalex.org/W1928773445","authors":[],"funders":[{"funder_name":"Istituto Toscano Tumori (ITT) ‘Correlation among epigenetic, environmental and genetic factors in colorectal carcinoma’","grant_id":"Prot. AOOGRT/325424/Q.80.110","title":null}],"total_grants":1,"fwci":0.9644,"citation_percentile":0.7403609,"influential_citations":0,"citation_trend":[{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":4},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":5},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.2217/epi.14.77","host_type":"publisher"},{"url":"https://doi.org/10.2217/epi.14.77","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25942531","host_type":"repository"},{"url":"http://hdl.handle.net/11568/760814","host_type":"repository"}],"fields_of_study":["Epigenetics and DNA Methylation","Genetic factors in colorectal cancer","Genetic Associations and Epidemiology","Aged","Colorectal Neoplasms","DNA Methylation","Diet","Female","Folic Acid","Gene-Environment Interaction","Humans","Life Style","Male","Middle Aged","Neural Networks, Computer","Polymorphism, Genetic","Promoter Regions, Genetic"],"mesh_terms":["Aged","Diet","Female","Folic Acid","Humans","Life Style","Male","Middle Aged","Polymorphism, Genetic","Promoter Regions, Genetic","Colorectal Neoplasms","Neural Networks, Computer","DNA Methylation","Gene-Environment Interaction"],"keywords":["Biology","DNA methylation","Colorectal cancer","Link (geometry)","Methylation","Artificial neural network","Genetics","Computational biology","DNA","Bioinformatics","Cancer","Artificial intelligence","Gene","Computer science","Gene expression","Computer network","APC","Folate","Artificial neural networks","MGMT","Polymorphisms","RASSF1A","MLH1","Cdkn2a"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T19:04:43.722472Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}