{"doi":"10.2217/epi-2023-0339","title":"Alteration of DNA Methyltransferases by Eribulin Elicits Broad DNA Methylation Changes with Potential Therapeutic Implications for Triple-Negative Breast Cancer","abstract":"Background: Triple-negative breast cancer (TNBC) is an aggressive disease with limited treatment options. Eribulin, a chemotherapeutic drug, induces epigenetic changes in cancer cells, suggesting a unique mechanism of action. Materials & methods: MDA-MB 231 cells were treated with eribulin and paclitaxel, and the samples from 53 patients treated with neoadjuvant eribulin were compared with those from 14 patients who received the standard-of-care treatment using immunohistochemistry. Results: Eribulin treatment caused significant DNA methylation changes in drug-tolerant persister TNBC cells, and it also elicited changes in the expression levels of epigenetic modifiers (DNMT1, TET1, DNMT3A/B) in vitro and in primary TNBC tumors. Conclusion: These findings provide new insights into eribulin’s mechanism of action and potential biomarkers for predicting TNBC treatment response.","journal":"Epigenomics","year":2024,"id":446400,"datarank":0.38061490800250697,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.08872838564420991,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.08872838564420991,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":6,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8888,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":474499,"name":"Min Kyung Lee","orcid":"0000-0001-9558-4819","position":1,"is_corresponding":false},{"id":498083,"name":"Kristen E. Muller","orcid":"0000-0003-3166-4523","position":2,"is_corresponding":false},{"id":438424,"name":"W. Todd Miller","orcid":"0000-0002-6566-0064","position":3,"is_corresponding":false},{"id":498084,"name":"Diwakar R. Pattabiraman","orcid":"0000-0002-2418-6458","position":4,"is_corresponding":false},{"id":14596,"name":"Brock C. Christensen","orcid":"0000-0003-3022-426X","position":5,"is_corresponding":false},{"id":498080,"name":"Meisam Bagheri","orcid":"0000-0002-5468-321X","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:50.465308Z","pmid":"38356412","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}