{"doi":"10.2217/epi-2023-0263","title":"Maternal Caffeine Consumption During Pregnancy and Offspring Cord Blood DNA Methylation: An Epigenome-Wide Association Study Meta-Analysis","abstract":"Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12–22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.","journal":"Epigenomics","year":2023,"id":387131,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9223,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1155953,"name":"Giulietta S. Monasso","orcid":"0000-0002-5773-5580","position":1,"is_corresponding":false},{"id":50531,"name":"Janine F. Felix","orcid":"0000-0002-9801-5774","position":2,"is_corresponding":false},{"id":279629,"name":"Vincent W. V. Jaddoe","orcid":"0000-0003-2939-0041","position":3,"is_corresponding":false},{"id":1126409,"name":"Peiyuan Huang","orcid":"0000-0002-8562-9152","position":4,"is_corresponding":false},{"id":484756,"name":"Sílvia Fernández‐Barrés","orcid":"0000-0002-9977-2291","position":5,"is_corresponding":false},{"id":39292,"name":"Martine Vrijheid","orcid":"0000-0002-7090-1758","position":6,"is_corresponding":false},{"id":565940,"name":"Giancarlo Pesce","orcid":"0000-0003-4925-6325","position":7,"is_corresponding":false},{"id":395096,"name":"Isabella Annesi‐Maesano","orcid":"0000-0002-6340-9300","position":8,"is_corresponding":false},{"id":5160,"name":"Christian M. Page","orcid":"0000-0002-1897-3666","position":9,"is_corresponding":false},{"id":392766,"name":"Anne Lise Brantsæter","orcid":"0000-0001-6315-7134","position":10,"is_corresponding":false},{"id":675311,"name":"Mona Bekkhus","orcid":"0000-0002-4447-8909","position":11,"is_corresponding":false},{"id":5169,"name":"Siri E. Håberg","orcid":"0000-0002-2199-5225","position":12,"is_corresponding":false},{"id":5170,"name":"Stephanie J. London","orcid":"0000-0003-4911-5290","position":13,"is_corresponding":false},{"id":6136,"name":"Marcus Robert Munafo","orcid":"0000-0002-4049-993X","position":14,"is_corresponding":false},{"id":14719,"name":"Luisa Zuccolo","orcid":"0000-0002-7049-3037","position":15,"is_corresponding":false},{"id":270431,"name":"Gemma C. Sharp","orcid":"0000-0003-2906-4035","position":16,"is_corresponding":false},{"id":1155952,"name":"Laura Schellhas","orcid":"0000-0001-6436-4821","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:18:04.706547Z","pmid":"38018434","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}