{"doi":"10.2217/epi-2021-0078","title":"Neonatal necrotizing enterocolitis-associated DNA methylation signatures in the colon are evident in stool samples of affected individuals","abstract":"Aim: Neonatal necrotizing enterocolitis (NEC) is a deadly and unpredictable gastrointestinal disease, for which no biomarker exists. We aimed to describe the methylation patterns in stool and colon from infants with NEC. Methods: We performed a high-resolution genome-wide epigenomic analysis using solution-phase hybridization and next-generation sequencing of bisulfite-converted DNA. Results: Our data reveal significant genomic hypermethylation in NEC tissues compared with non-NEC controls. These changes were more pronounced in regions outside CpG islands and gene regulatory elements, suggesting that NEC-specific hypermethylation is not a nonspecific global phenomenon. Conclusions: This study provides evidence of a methylomic signature associated with NEC that is detectable noninvasively and provides a new opportunity for the development of a novel diagnostic method for NEC.","journal":"Epigenomics","year":2021,"id":187778,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9415,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":504594,"name":"Tianjiao Chu","orcid":"0000-0001-9644-771X","position":1,"is_corresponding":false},{"id":504595,"name":"Patricia Shaw","orcid":"0000-0002-6994-8647","position":2,"is_corresponding":false},{"id":273934,"name":"Lila S. Nolan","orcid":"0000-0002-4185-2686","position":3,"is_corresponding":false},{"id":505565,"name":"Lora McClain","orcid":null,"position":4,"is_corresponding":false},{"id":505566,"name":"Austin Chamberlain","orcid":null,"position":5,"is_corresponding":false},{"id":504596,"name":"Carlos A. Castro","orcid":"0000-0003-2419-3604","position":6,"is_corresponding":false},{"id":504597,"name":"Qingqing Gong","orcid":"0009-0003-2425-1701","position":7,"is_corresponding":false},{"id":504598,"name":"Krista Cooksey","orcid":"0000-0001-7236-0089","position":8,"is_corresponding":false},{"id":505568,"name":"Laura Linneman","orcid":null,"position":9,"is_corresponding":false},{"id":710639,"name":"Olivia DeWitt","orcid":null,"position":10,"is_corresponding":false},{"id":504600,"name":"David N. Finegold","orcid":"0000-0001-9901-2578","position":11,"is_corresponding":false},{"id":504601,"name":"David G. Peters","orcid":"0000-0003-4354-1125","position":12,"is_corresponding":false},{"id":273935,"name":"Misty Good","orcid":"0000-0002-0264-5721","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:48:55.420619Z","pmid":"33905263","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}