{"doi":"10.2217/bmm-2022-0653","title":"Papp-A As A Screening Tool for Assessment of Gestational Age Before Medication Abortion in An Intended-Use Population","abstract":"Introduction: Prior studies indicate that PAPP-A could serve as a marker of gestational age (GA) with the potential to determine eligibility for medication abortion. The authors validated the relationship between PAPP-A and GA in an actual-use population. Materials & methods: The authors collected blood samples, medical histories and ultrasound-determined GA from patients presenting for abortion services. They measured PAPP-A using two immunoassays and assessed diagnostic accuracy for predicting GA ≥71 days. Results: The Ansh Labs and R&D Systems immunoassays produced an area under the ROC curve of 0.982 (95% CI: 0.958–0.994) and 0.986 (95% CI: 0.963–0.996), respectively, for predicting GA ≥71 days. Conclusion: This validation study in an intended-use population confirmed that PAPP-A has a strong ability to distinguish pregnancies above and below 71 days' gestation. Clinical trial registration: NCT04232189 (ClinicalTrials.gov)","journal":"Biomarkers in Medicine","year":2023,"id":383177,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9134,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04232189"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":339238,"name":"Irina A. Buhimschi","orcid":"0000-0002-1701-1326","position":1,"is_corresponding":false},{"id":852316,"name":"Elizabeth G. Raymond","orcid":null,"position":2,"is_corresponding":false},{"id":339234,"name":"Guomao Zhao","orcid":"0000-0003-4120-8644","position":3,"is_corresponding":false},{"id":851682,"name":"Beverly Winikoff","orcid":"0000-0003-0876-0058","position":4,"is_corresponding":false},{"id":1150023,"name":"Laura J. Frye","orcid":"0000-0001-7280-1171","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T01:17:25.158896Z","pmid":"37038980","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}