{"doi":"10.2215/cjn.08350719","title":"Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD","abstract":"Background and objectives Exposure to particulate matter (PM) <2.5 μ m in aerodynamic diameter (PM 2.5 ) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM 2.5 exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD. Design, setting, participants, & measurements The study included 10,997 participants from the Atherosclerosis Risk in Communities cohort who were followed from 1996–1998 through 2016. Monthly mean PM 2.5 concentrations ( μ g/m 3 ) were estimated at geocoded participant addresses using geographic information system–based, spatiotemporal generalized additive mixed models—including geospatial covariates such as land use—and then averaged over the 12-month period preceding participant examination. Covariate-adjusted, cross-sectional associations of PM 2.5 , baseline eGFR, and urinary albumin-creatinine ratio (UACR) were estimated using linear regression. PM 2.5 and incident CKD (defined as follow-up eGFR <60 ml/min per 1.73 m 2 with ≥25% eGFR decline relative to baseline, CKD-related hospitalization or death based on International Classification of Diseases 9/10 codes, or development of ESKD) associations were estimated using Cox proportional hazards regression. Modeling was stratified by study site, and stratum-specific estimates were combined using random-effects meta-analyses. Results Baseline mean participant age was 63 (±6) years and eGFR was 86 (±16) ml/min per 1.73 m 2 . There was no significant PM 2.5 -eGFR association at baseline. Each 1- μ g/m 3 higher annual average PM 2.5 was associated with higher UACR after adjusting for demographics, socioeconomic status, and clinical covariates (percentage difference, 6.6%; 95% confidence interval [95% CI], 2.6% to 10.7%). Each 1- μ g/m 3 higher annual average PM 2.5 was associated with a significantly higher risk of incident CKD (hazard ratio, 1.05; 95% CI, 1.01 to 1.10). Conclusions Exposure to higher annual average PM 2.5 concentrations was associated with a higher level of albuminuria and higher risk for incident CKD in a community-based cohort.","journal":"Clinical Journal of the American Society of Nephrology","year":2020,"id":53824,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":111,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9048,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":232664,"name":"Aditya Surapaneni","orcid":"0000-0003-4978-5980","position":1,"is_corresponding":false},{"id":275264,"name":"James D. Stewart","orcid":"0000-0002-2776-6570","position":2,"is_corresponding":false},{"id":275265,"name":"Duanping Liao","orcid":"0000-0001-7405-6152","position":3,"is_corresponding":false},{"id":275266,"name":"Jeff D. Yanosky","orcid":"0000-0002-6196-655X","position":4,"is_corresponding":false},{"id":218550,"name":"Eric A. Whitsel","orcid":"0000-0003-4843-3641","position":5,"is_corresponding":false},{"id":275267,"name":"Melinda C. Power","orcid":"0000-0001-9099-7964","position":6,"is_corresponding":false},{"id":73169,"name":"Morgan E. Grams","orcid":"0000-0002-4430-6023","position":7,"is_corresponding":false},{"id":275263,"name":"Matthew F. Blum","orcid":"0000-0003-4357-6926","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T20:45:25.145885Z","pmid":"32108020","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}