{"doi":"10.2215/cjn.05870611","title":"Reversibility of the Effects of Aliskiren in the Renal Versus Systemic Circulation","abstract":"<jats:title>Summary</jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives</jats:title>\n                    <jats:p>Renal hemodynamic effects of inhibitors of the renin-angiotensin system can increase the risk of acute kidney injury under certain conditions. The BP-lowering effects of the renin inhibitor aliskiren are sustained 3–4 weeks after withdrawal. In this study, the reversibility of the renal hemodynamic effects of aliskiren was tested.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements</jats:title>\n                    <jats:p>In this open-label study, renal perfusion was measured by 1.5-T magnetic resonance imaging–arterial spin labeling in 34 subjects with arterial hypertension before aliskiren (pre-aliskiren), after 4 weeks of aliskiren treatment (300 mg), and 4–5 days (∼2.5–3.0× plasma half-life) after withdrawal (post-aliskiren).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      Aliskiren reduced systolic BP from 152 ± 14 to 139 ± 16 mmHg (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      &lt;0.0001), which was sustained post-aliskiren (136 ± 13 mmHg,\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      =1.00 versus aliskiren). Aliskiren significantly altered renal perfusion (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      =0.005), increasing from 272 ± 25 pre-aliskiren to 287 ± 29 ml/min per 100 g during aliskiren (\n                      <jats:italic toggle=\"yes\">P=</jats:italic>\n                      0.03). This increase in renal perfusion was completely reversed post-aliskiren (272 ± 26 ml/min per 100 g,\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      =0.03 versus aliskiren,\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      =0.63 versus pre-aliskiren). No changes were noted in urinary angiotensinogen levels. Plasma renin activity was reduced by aliskiren, which was sustained post-aliskiren. Angiotensin II and aldosterone were reduced by aliskiren but recovered post-aliskiren to pre-aliskiren levels.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p>After withdrawal of aliskiren, the effects on BP were sustained, whereas increase in renal perfusion was reversed, which was associated with recovery of angiotensin II and aldosterone to pretreatment levels. Renal hemodynamic effects are more readily reversible than systemic effects of aliskiren.</jats:p>\n                  </jats:sec>","journal":"Clinical Journal of the American Society of Nephrology","year":2012,"id":683108,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1784508,"name":"Rolf Janka","orcid":null,"position":1,"is_corresponding":false},{"id":1113635,"name":"Thomas Ziegler","orcid":"0000-0002-4797-609X","position":2,"is_corresponding":false},{"id":1784509,"name":"Ulrike Raff","orcid":null,"position":3,"is_corresponding":false},{"id":1784510,"name":"Martin Ritt","orcid":null,"position":4,"is_corresponding":false},{"id":1784511,"name":"Christian Ott","orcid":null,"position":5,"is_corresponding":false},{"id":1784512,"name":"Roland Veelken","orcid":null,"position":6,"is_corresponding":false},{"id":1555486,"name":"Michael Uder","orcid":null,"position":7,"is_corresponding":false},{"id":1677587,"name":"Roland E. Schmieder","orcid":null,"position":8,"is_corresponding":false},{"id":854360,"name":"Markus P. Schneider","orcid":"0000-0002-5265-8088","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Reversibility of the Effects of Aliskiren in the Renal Versus Systemic Circulation","abstract":"<jats:title>Summary</jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives</jats:title>\n                    <jats:p>Renal hemodynamic effects of inhibitors of the renin-angiotensin system can increase the risk of acute kidney injury under certain conditions. The BP-lowering effects of the renin inhibitor aliskiren are sustained 3–4 weeks after withdrawal. In this study, the reversibility of the renal hemodynamic effects of aliskiren was tested.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements</jats:title>\n                    <jats:p>In this open-label study, renal perfusion was measured by 1.5-T magnetic resonance imaging–arterial spin labeling in 34 subjects with arterial hypertension before aliskiren (pre-aliskiren), after 4 weeks of aliskiren treatment (300 mg), and 4–5 days (∼2.5–3.0× plasma half-life) after withdrawal (post-aliskiren).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      Aliskiren reduced systolic BP from 152 ± 14 to 139 ± 16 mmHg (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      &lt;0.0001), which was sustained post-aliskiren (136 ± 13 mmHg,\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      =1.00 versus aliskiren). Aliskiren significantly altered renal perfusion (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      =0.005), increasing from 272 ± 25 pre-aliskiren to 287 ± 29 ml/min per 100 g during aliskiren (\n                      <jats:italic toggle=\"yes\">P=</jats:italic>\n                      0.03). This increase in renal perfusion was completely reversed post-aliskiren (272 ± 26 ml/min per 100 g,\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      =0.03 versus aliskiren,\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      =0.63 versus pre-aliskiren). No changes were noted in urinary angiotensinogen levels. Plasma renin activity was reduced by aliskiren, which was sustained post-aliskiren. Angiotensin II and aldosterone were reduced by aliskiren but recovered post-aliskiren to pre-aliskiren levels.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p>After withdrawal of aliskiren, the effects on BP were sustained, whereas increase in renal perfusion was reversed, which was associated with recovery of angiotensin II and aldosterone to pretreatment levels. Renal hemodynamic effects are more readily reversible than systemic effects of aliskiren.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22173856","pmcid":"PMC3280021","openalex_id":"https://openalex.org/W2148312174","authors":[],"funders":[],"total_grants":0,"fwci":0.7187,"citation_percentile":0.75357347,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":3},{"year":2021,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3280021","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3280021","host_type":"repository"},{"url":"https://www.ovid.com/01277230-201202000-00010","host_type":"publisher"},{"url":"https://doi.org/10.2215/cjn.05870611","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22173856","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3280021","host_type":"repository"}],"fields_of_study":["Renin-Angiotensin System Studies","Acute Kidney Injury Research","Hormonal Regulation and Hypertension","Adult","Aged","Aldosterone","Amides","Analysis of Variance","Angiotensin II","Antihypertensive Agents","Blood Pressure","Female","Fumarates","Germany","Half-Life","Humans","Hypertension","Magnetic Resonance Imaging","Male","Middle Aged","Perfusion Imaging","Renal Circulation","Renin","Renin-Angiotensin System","Time Factors","Treatment Outcome","Vasodilation","Vasodilator Agents","Renin Inhibitors"],"mesh_terms":["Renin Inhibitors","Adult","Aged","Aldosterone","Amides","Analysis of Variance","Angiotensin II","Antihypertensive Agents","Blood Pressure","Female","Fumarates","Germany","Half-Life","Humans","Hypertension","Magnetic Resonance Imaging","Male","Middle Aged","Renal Circulation","Renin","Renin-Angiotensin System","Time Factors","Vasodilation","Vasodilator Agents","Treatment Outcome","Perfusion Imaging"],"keywords":["Aliskiren","Renin inhibitor","Medicine","Renin–angiotensin system","Internal medicine","Plasma renin activity","Perfusion","Endocrinology","Urology","Cardiology","Blood pressure"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T22:24:19.107991Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}