{"doi":"10.2196/85140","title":"A Telehealth-Based Behavioral Intervention for Cancer-Related Cognitive Decline in Older Adults Undergoing Systemic Therapy for Breast Cancer: Development and Usability Testing","abstract":"Background: Cancer-related cognitive decline (CRCD) is a significant problem; interventions are needed to mitigate CRCD for older adults (aged ≥65 years). Objective: Our objective was to develop and evaluate the usability of Memory and Attention Adaptation Training-Geriatrics (MAAT-G), a CRCD intervention for older adults with breast cancer undergoing systemic treatment. Methods: We conducted an intervention adaptation study to develop MAAT-G. MAAT-G is a cognitive behavioral therapy-based intervention delivered by a health professional over the course of 10 weekly individual workshops via videoconferencing. To develop MAAT-G, the contextual, cohort-based, maturity, and specific challenge framework was used for preliminary adaptations. Patient advocate collaborators guided further refinement, reviewing MAAT-G workshop content, the participant workbook, and intervention delivery via videoconferencing to optimize relevance and usability for older adults. The usability of MAAT-G and its videoconferencing delivery were subsequently evaluated in 4 older adults with breast cancer using the System Usability Scale (score range 0-100; >67 being above average) and through semistructured qualitative interviews. Results: Numerous adaptations were made to address the unique needs of older patients using the contextual, cohort-based, maturity, and specific challenge framework and patient advocate feedback. Usability testing included 4 female patients with breast cancer (mean age 73.3, SD 3.77; range 67-77 years). Patients were receiving systemic therapy (2 receiving adjuvant therapy and 2 receiving advanced-stage disease therapy). One patient had an educational level lower than high school; 3 had some college education or higher. All 4 patients completed study procedures, including 10 MAAT-G workshop sessions (100% intervention adherence). The mean System Usability Scale score was 90.6 (SD 13.51), indicating good usability. Conclusions: MAAT-G is a behavioral intervention developed to mitigate CRCD. It is designed specifically for older adults and showed above-average usability in this population.","journal":"JMIR Formative Research","year":2025,"id":549603,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.962,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1187449,"name":"L. Berkhof","orcid":null,"position":1,"is_corresponding":false},{"id":1240528,"name":"Oscar Y. Franco‐Rocha","orcid":"0000-0002-5547-1518","position":2,"is_corresponding":false},{"id":1444321,"name":"L. Mustian","orcid":null,"position":3,"is_corresponding":false},{"id":575284,"name":"Valerie Targia","orcid":null,"position":4,"is_corresponding":false},{"id":1443814,"name":"Jessica Bauer","orcid":"0009-0005-7565-2518","position":5,"is_corresponding":false},{"id":1443815,"name":"Jessica Mortimer","orcid":"0009-0004-9121-9127","position":6,"is_corresponding":false},{"id":1443816,"name":"Grace DiGiovanni","orcid":"0009-0001-5794-2897","position":7,"is_corresponding":false},{"id":1251865,"name":"Daniel Millstein","orcid":"0000-0003-0204-3883","position":8,"is_corresponding":false},{"id":1444322,"name":"Kassandra Scioli","orcid":null,"position":9,"is_corresponding":false},{"id":1444323,"name":"H. D'Aurizio","orcid":null,"position":10,"is_corresponding":false},{"id":1443817,"name":"Lauren DeCaporale-Ryan","orcid":"0000-0001-7228-2447","position":11,"is_corresponding":false},{"id":266566,"name":"Supriya G. Mohile","orcid":"0000-0003-0867-327X","position":12,"is_corresponding":false},{"id":278742,"name":"Michelle C. Janelsins","orcid":"0000-0003-2258-7247","position":13,"is_corresponding":false},{"id":992499,"name":"Robert J. Ferguson","orcid":"0000-0001-9711-022X","position":14,"is_corresponding":false},{"id":369203,"name":"Alissa Huston","orcid":"0009-0004-5247-9567","position":15,"is_corresponding":false},{"id":336516,"name":"Allison Magnuson","orcid":"0000-0002-0968-8265","position":16,"is_corresponding":false},{"id":1443813,"name":"J MacLaren Kelly","orcid":"0000-0003-4423-8670","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T02:54:07.823422Z","pmid":"41603881","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}