{"doi":"10.2196/33995","title":"Reasons for COVID-19 Vaccine Hesitancy Among Chinese People Living With HIV/AIDS: Structural Equation Modeling Analysis","abstract":"BACKGROUND: Many countries and organizations recommended people living with HIV/AIDS (PLWHA) receive the COVID-19 vaccine. However, vaccine hesitancy still exists and becomes a barrier for promoting COVID-19 vaccination among PLWHA. OBJECTIVE: This study aims to investigate factors that contributed to COVID-19 vaccine hesitancy among PLWHA. METHODS: The study used a multicenter cross-sectional design and an online survey mode. We recruited PLWHA aged 18-65 years from 5 metropolitan cities in China between January 2021 and February 2021. Participants completed an online survey through Golden Data, a widely used encrypted web-based survey platform. Multiple linear regression models were used to assess the background characteristics in relation to COVID-19 vaccine hesitancy, and structural equation modeling was performed to assess the relationships among perceived benefits, perceived risks, self-efficacy, subjective norms, and COVID-19 vaccine hesitancy. RESULTS: Among 1735 participants, 41.61% (722/1735) reported COVID-19 vaccine hesitancy. Older age, no other vaccinations in the past 3 years, and having chronic disease history were positively associated with COVID-19 vaccine hesitancy. Structural equation modeling revealed a direct relationship of perceived benefits, perceived risks, and subjective norms with self-efficacy and vaccine hesitancy and an indirect relationship of perceived benefits, perceived risks, and subjective norms with vaccine hesitancy. Moreover, self-efficacy toward COVID-19 vaccination was low. PLWHA had concerns of HIV disclosure during COVID-19 vaccination. Family member support could have an impact on COVID-19 vaccination decision-making. CONCLUSIONS: COVID-19 vaccine hesitancy was high among PLWHA in China. To reduce COVID-19 vaccine hesitancy, programs and strategies should be adopted to eliminate the concerns for COVID-19 vaccination, disseminate accurate information on the safety and efficacy of the COVID-19 vaccine, encourage family member support for COVID-19 vaccination, and improve PLWHA's trust of medical professionals.","journal":"JMIR Public Health and Surveillance","year":2022,"id":243301,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":875062,"name":"Ruiyu Chai","orcid":"0000-0001-7605-6981","position":1,"is_corresponding":false},{"id":667566,"name":"Jianzhou Yang","orcid":"0000-0001-5354-2290","position":2,"is_corresponding":false},{"id":667567,"name":"Xiangjun Zhang","orcid":"0000-0001-6682-2590","position":3,"is_corresponding":false},{"id":305161,"name":"Xiaojie Huang","orcid":"0000-0002-5045-9202","position":4,"is_corresponding":false},{"id":667564,"name":"Maohe Yu","orcid":"0000-0002-6282-1299","position":5,"is_corresponding":false},{"id":554088,"name":"Gengfeng Fu","orcid":"0000-0001-5099-2050","position":6,"is_corresponding":false},{"id":667565,"name":"Guanghua Lan","orcid":"0000-0002-5268-5772","position":7,"is_corresponding":false},{"id":430421,"name":"Ying Qiao","orcid":"0000-0003-4308-5633","position":8,"is_corresponding":false},{"id":875063,"name":"Qidi Zhou","orcid":"0000-0001-6698-4290","position":9,"is_corresponding":false},{"id":875064,"name":"Shuyue Li","orcid":"0000-0001-6459-239X","position":10,"is_corresponding":false},{"id":447561,"name":"Junjie Xu","orcid":"0000-0003-4303-7295","position":11,"is_corresponding":false},{"id":875061,"name":"Yan Yao","orcid":"0000-0002-1823-3684","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T00:23:16.032700Z","pmid":"35486810","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}