{"doi":"10.21873/invivo.12560","title":"Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients","abstract":null,"journal":"In Vivo","year":2021,"id":613948,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1581861,"name":"MAXIMILIAN EBERHARD HERMANN WAGNER","orcid":null,"position":1,"is_corresponding":false},{"id":1581863,"name":"CLAUDIA NEUNABER","orcid":null,"position":2,"is_corresponding":false},{"id":1581864,"name":"JAN-DIERK CLAUSEN","orcid":null,"position":3,"is_corresponding":false},{"id":1581865,"name":"MARCEL WINKELMANN","orcid":null,"position":4,"is_corresponding":false},{"id":1581859,"name":"KATHARINA LEDITZKE","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients","abstract":"<h4>Background</h4>Early detection of acute kidney injury (AKI) is crucial in the management of multiple-organ dysfunction syndrome in severely injured patients. Standard laboratory parameters usually increase with temporal delay. Therefore, we evaluated neutrophil gelatinase-associated lipocalin (NGAL) as an early marker for acute kidney injury.<h4>Patients and methods</h4>We retrospectively evaluated patients admitted to a level 1 trauma center. We collected clinicodemographic data and measured kidney-related factors and plasma cytokines.<h4>Results</h4>A total of 39 patients were included. Patients with AKI had significantly higher levels not only of serum creatinine and urea, but also of NGAL (all p<0.001) than patients without AKI. The optimal NGAL cut-off value was determined to be 177 ng/ml, showing significant correlation with imminent or manifest AKI (p<0.001). Other independent markers correlated with AKI included pre-existing chronic kidney disease, use of catecholamines, and severe injury (p<0.001).<h4>Conclusion</h4>The serum level of NGAL is feasible early predictor of AKI.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34410965","pmcid":"PMC8408701","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":null,"oa_locations":[{"url":"https://syndication.highwire.org/content/doi/10.21873/invivo.12560","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Acute-Phase Proteins","Proto-Oncogene Proteins","Retrospective Studies","Lipocalins","Acute Kidney Injury","Biomarkers","Lipocalin-2"],"keywords":["Acute Kidney Injury","Multiple Trauma","Lcn2","Neutrophil Gelatinase-associated Lipocalin","Lipocalin 2","Acute Kidney Failure","Multiple-organ Failure","Multiple-organ Dysfunction Syndrome"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T09:49:35.931909Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}