{"doi":"10.21873/invivo.12470","title":"The Combination PARP Inhibitor Olaparib With Temozolomide in an Experimental Glioblastoma Model","abstract":null,"journal":"In Vivo","year":2021,"id":687257,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1795447,"name":"JIN-HAN LEE","orcid":null,"position":1,"is_corresponding":false},{"id":1795449,"name":"SANG HO KIM","orcid":null,"position":2,"is_corresponding":false},{"id":1795450,"name":"KYEONG-O GO","orcid":null,"position":3,"is_corresponding":false},{"id":1795451,"name":"SO YOUNG JI","orcid":null,"position":4,"is_corresponding":false},{"id":1795452,"name":"JUNG HO HAN","orcid":null,"position":5,"is_corresponding":false},{"id":1795453,"name":"CHAE-YONG KIM","orcid":null,"position":6,"is_corresponding":false},{"id":1795445,"name":"KIHWAN HWANG","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Combination PARP Inhibitor Olaparib With Temozolomide in an Experimental Glioblastoma Model","abstract":"BACKGROUND/AIM: Poly (ADP-ribose) polymerase (PARP) inhibition could enhance the efficacy of temozolomide and prolong survival in patients with glioblastoma. The aim of this study was to evaluate the combination of the PARP inhibitor olaparib with temozolomide in the treatment of glioblastoma. MATERIALS AND METHODS: -methylguanine methyltransferase (MGMT) promoter-methylated (U87MG, U251MG) and MGMT promoter-unmethylated (T98G) glioblastoma cell lines using In this model cell viability and apoptosis were assessed. For the in vivo studies, nude mice bearing orthotopically xenografted glioblastoma cell lines (U87MG) were randomized to four experimental groups: i) the untreated, ii) temozolomide alone, iii) olaparib alone and iv) olaparib and temozolomide combination groups. Mice were treated daily for 4 weeks and monitored for tumor growth and survival. RESULTS: In vitro we found that the combination of olaparib with temozolomide enhanced temozolomide-induced cytotoxicity in all glioblastoma cell lines regardless of the status of MGMT promoter methylation. In vivo, mice treated with temozolomide alone or in combination with olaparib showed greater survival than those untreated or with the olaparib monotherapy, as well as significantly decreased tumor volume. There was no significant difference in survival and tumor volume between temozolomide alone and the combination treatment. CONCLUSION: The combination of the PARP inhibitor olaparib with temozolomide could be promising candidates for combination therapy of glioblastoma regardless of the MGMT promoter methylation status.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34182476","pmcid":"PMC8286506","openalex_id":"https://openalex.org/W3175416687","authors":[],"funders":[],"total_grants":0,"fwci":1.135,"citation_percentile":0.81025228,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":7},{"year":2025,"count":6},{"year":2026,"count":5}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://iv.iiarjournals.org/content/invivo/35/4/2015.full.pdf","host_type":"journal"},{"url":"https://iv.iiarjournals.org/content/invivo/35/4/2015.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.21873/invivo.12470","host_type":"publisher"},{"url":"https://doi.org/10.21873/invivo.12470","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34182476","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8286506","host_type":"repository"}],"fields_of_study":["PARP inhibition in cancer therapy","Glioma Diagnosis and Treatment","Telomeres, Telomerase, and Senescence","Animals","Antineoplastic Agents, Alkylating","Brain Neoplasms","Cell Line, Tumor","DNA Methylation","Glioblastoma","Humans","Mice","Mice, Nude","Phthalazines","Piperazines","Poly(ADP-ribose) Polymerase Inhibitors","Temozolomide"],"mesh_terms":["Poly(ADP-ribose) Polymerase Inhibitors","Temozolomide","Animals","Brain Neoplasms","Glioblastoma","Humans","Mice, Nude","Phthalazines","Piperazines","Antineoplastic Agents, Alkylating","DNA Methylation","Cell Line, Tumor","Mice"],"keywords":["Temozolomide","Olaparib","PARP inhibitor","Cancer research","Medicine","In vivo","Poly ADP ribose polymerase","Pharmacology","Glioma","Chemistry","Biology","Polymerase","Enzyme","Biochemistry","Glioblastoma","Combination chemotherapy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T21:38:57.182273Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}