{"doi":"10.21873/invivo.12038","title":"Indocyanine Green Labels an Orthotopic Nude-Mouse Model of Very-Early Colon-Cancer Liver Metastases","abstract":"BACKGROUND/AIM: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) is used to visualize colon-cancer liver metastases (CCLM) during surgery. The present study aimed to use ICG to visualize small CCLM in an orthotopic mouse model. MATERIALS AND METHODS: A 3-mm fragment of HT29 human colon cancer was implanted to the liver of 5 athymic nude mice (nu/nu). The Pearl Trilogy Small Animal Fluorescence Imaging system was used 24 h after intravenous (IV) injection of 0.025 mg (0.25 mg/ml) ICG. RESULTS: In four of the five mice, tumor fluorescence was detected. Small tumors (approximately 3 mm) were distinctly visualized with a minimal fluorescence liver signal, with a mean tumor to liver signal ratio of 1.81 (SD±0.167). CONCLUSION: Small CCLM can be clearly identified by ICG fluorescence in an orthotopic nude-mouse model. This model is translatable to the clinic for the detection of occult early CCLM.","journal":"In Vivo","year":2020,"id":110593,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":227846,"name":"Hannah M. Hollandsworth","orcid":"0000-0002-8867-6835","position":1,"is_corresponding":false},{"id":428098,"name":"Hiroto Nishino","orcid":"0000-0002-7377-9997","position":2,"is_corresponding":false},{"id":428100,"name":"Jun Yamamoto","orcid":"0000-0003-2591-5023","position":3,"is_corresponding":false},{"id":432271,"name":"Siamak Amirfakhri","orcid":"0000-0002-5534-1043","position":4,"is_corresponding":false},{"id":429219,"name":"Filemoni Filemoni","orcid":null,"position":5,"is_corresponding":false},{"id":428099,"name":"Norihiko Sugisawa","orcid":"0000-0003-1887-7268","position":6,"is_corresponding":false},{"id":525786,"name":"Takeshi Aoki","orcid":"0000-0002-0503-2525","position":7,"is_corresponding":false},{"id":525787,"name":"Masahiko Murakami","orcid":"0000-0001-6233-5015","position":8,"is_corresponding":false},{"id":370841,"name":"Robert M. Hoffman","orcid":"0000-0002-0049-0041","position":9,"is_corresponding":false},{"id":399592,"name":"Michael Bouvet","orcid":"0000-0002-0086-2159","position":10,"is_corresponding":false},{"id":428101,"name":"Yoshihiko Tashiro","orcid":"0000-0002-8574-5305","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-18T23:12:57.988348Z","pmid":"32871750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}