{"doi":"10.21873/anticanres.15148","title":"Bromodomain-containing Protein 4 Is a Favourable Prognostic Factor in Breast Cancer Patients","abstract":"AIM: To evaluate the association between bromodomain-containing protein 4 (BRD4) expression and clinicopathological factors and prognosis in human breast cancer specimens. PATIENTS AND METHODS: We used tissue microarrays constructed from samples of patients (n=183) who underwent surgery. We validated the association between BRD4 expression and prognosis in solid tumours, including breast cancer, using The Cancer Genome Atlas (TCGA) database. RESULTS: Immunohistochemical staining showed that BRD4 was widely distributed in breast cancer tissues. BRD4 was strongly expressed in 19.7% of patients but BRD4 staining intensity was not correlated with other clinicopathological factors. Most importantly, patients with a strong BRD4 expression had a significantly longer disease-specific survival than those with a weak BRD4 expression (100.0% vs. 91.3% at 5 years, p=0.027). mRNA expression analysis showed similar results (91.2% vs. 80.2% at 6 years, p=0.047). CONCLUSION: Strong BRD4 expression was associated with a significantly better prognosis in breast cancer tumours.","journal":"Anticancer Research","year":2021,"id":212033,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7986,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":530787,"name":"Akimitsu Yamada","orcid":"0000-0003-3006-0648","position":1,"is_corresponding":false},{"id":531361,"name":"Shoko Adachi","orcid":null,"position":2,"is_corresponding":false},{"id":530789,"name":"Hidetaka Shima","orcid":"0000-0002-4913-1648","position":3,"is_corresponding":false},{"id":530790,"name":"Kumiko Kida","orcid":"0000-0002-0946-5053","position":4,"is_corresponding":false},{"id":243272,"name":"Masanori Oshi","orcid":"0000-0002-1404-1570","position":5,"is_corresponding":false},{"id":802012,"name":"Sadatoshi Sugae","orcid":"0000-0002-4716-7743","position":6,"is_corresponding":false},{"id":530791,"name":"Shinya Yamamoto","orcid":"0000-0002-8083-5387","position":7,"is_corresponding":false},{"id":530792,"name":"Kazutaka Narui","orcid":"0000-0002-0135-5001","position":8,"is_corresponding":false},{"id":531362,"name":"Mikiko Tanabe","orcid":null,"position":9,"is_corresponding":false},{"id":243279,"name":"Kazuaki Takabe","orcid":"0000-0002-6435-4241","position":10,"is_corresponding":false},{"id":530795,"name":"Yasushi Ichikawa","orcid":"0000-0002-7866-2907","position":11,"is_corresponding":false},{"id":243277,"name":"Takashi Ishikawa","orcid":"0000-0003-3450-4533","position":12,"is_corresponding":false},{"id":243278,"name":"Itaru Endo","orcid":"0000-0001-5520-8114","position":13,"is_corresponding":false},{"id":530788,"name":"Chiho Suzuki‐Minakuchi","orcid":"0000-0001-6622-1955","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T23:52:23.670339Z","pmid":"34230156","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}