{"doi":"10.21873/anticanres.13559","title":"The Effects of Eribulin on Breast Cancer Microenvironment Identified Using Eribulin-resistant Breast Cancer Cell Lines","abstract":null,"journal":"Anticancer Research","year":2019,"id":599021,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1535266,"name":"SHINICHIRO KASHIWAGI","orcid":null,"position":1,"is_corresponding":false},{"id":1535267,"name":"YUKA ASANO","orcid":null,"position":2,"is_corresponding":false},{"id":1535268,"name":"KOJI TAKADA","orcid":null,"position":3,"is_corresponding":false},{"id":1535269,"name":"KATSUYUKI TAKAHASHI","orcid":null,"position":4,"is_corresponding":false},{"id":1535270,"name":"HISAKAZU FUJITA","orcid":null,"position":5,"is_corresponding":false},{"id":1535271,"name":"TSUTOMU TAKASHIMA","orcid":null,"position":6,"is_corresponding":false},{"id":1535272,"name":"MASATSUNE SHIBUTANI","orcid":null,"position":7,"is_corresponding":false},{"id":1535273,"name":"RYOSUKE AMANO","orcid":null,"position":8,"is_corresponding":false},{"id":1535274,"name":"SHUHEI TOMITA","orcid":null,"position":9,"is_corresponding":false},{"id":1535275,"name":"KOSEI HIRAKAWA","orcid":null,"position":10,"is_corresponding":false},{"id":1535276,"name":"MASAICHI OHIRA","orcid":null,"position":11,"is_corresponding":false},{"id":1535265,"name":"WATARU GOTO","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Effects of Eribulin on Breast Cancer Microenvironment Identified Using Eribulin-resistant Breast Cancer Cell Lines","abstract":"BACKGROUND/AIM: Eribulin is currently used to treat advanced and metastatic breast cancer in the clinical setting; however, its efficacy is inhibited by resistance acquisition in many cases. Thus, the present study established two eribulin-resistant breast-cancer cell lines, and used these to investigate the mechanisms that underly eribulin-resistance acquisition. MATERIALS AND METHODS: Eribulin-resistant breast-cancer cell lines were generated by culturing MDA-MB-231 and MCF-7 cells with increasing concentrations of eribulin. RESULTS: The eribulin-resistant cells acquired resistance to eribulin, as well as several other anticancer drugs. After eribulin treatment, the eribulin-resistant cell lines showed no morphological change, no increased expression of epithelial-cadherin, nor any significant alteration in cell-cycle distribution. In contrast, the expression levels of programmed death-ligand 1 were increased in the MCF-7/eribulin-resistant compared to MCF-7 cells. CONCLUSION: The herein developed eribulin-resistant cell lines acquired cross-resistance to various anticancer agents, and displayed resistance to eribulin-induced effects on microtubule function and epithelial-mesenchymal transition (EMT).","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31366485","pmcid":null,"openalex_id":"https://openalex.org/W2965620940","authors":[],"funders":[],"total_grants":0,"fwci":0.8992,"citation_percentile":0.76532113,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://ar.iiarjournals.org/content/39/8/4031.full.pdf","host_type":"journal"},{"url":"http://ar.iiarjournals.org/content/39/8/4031.full.pdf","host_type":"publisher"},{"url":"https://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13559","host_type":"publisher"},{"url":"https://doi.org/10.21873/anticanres.13559","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31366485","host_type":"repository"}],"fields_of_study":["Cancer Treatment and Pharmacology","Flavonoids in Medical Research","Curcumin's Biomedical Applications","Animals","Antineoplastic Agents","Breast","Breast Neoplasms","Cell Cycle","Drug Resistance, Neoplasm","Epithelial-Mesenchymal Transition","Female","Furans","Humans","Ketones","MCF-7 Cells","Mice","Tumor Microenvironment","Xenograft Model Antitumor Assays","Polyether Polyketides"],"mesh_terms":["Polyether Polyketides","Animals","Antineoplastic Agents","Breast","Breast Neoplasms","Cell Cycle","Female","Furans","Humans","Ketones","Drug Resistance, Neoplasm","Xenograft Model Antitumor Assays","Mice","Epithelial-Mesenchymal Transition","Tumor Microenvironment","MCF-7 Cells"],"keywords":["Eribulin","Breast cancer","Cancer research","Metastatic breast cancer","Medicine","Internal medicine","Cancer","Oncology","Resistance","Microenvironment","Epithelial-mesenchymal Transition"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:44:48.504407Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}