{"doi":"10.21873/anticanres.11195","title":"Apoptosis of Hepatitis B Virus-expressing Liver Tumor Cells Induced by a High Concentration of Nucleos(t)ide Analogue","abstract":null,"journal":"Anticancer Research","year":2016,"id":650130,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1695095,"name":"SHIN HWANG","orcid":null,"position":1,"is_corresponding":false},{"id":1695096,"name":"HAN CHU LEE","orcid":null,"position":2,"is_corresponding":false},{"id":1695097,"name":"GI-YOUNG KO","orcid":null,"position":3,"is_corresponding":false},{"id":1695098,"name":"CHUL-SOO AHN","orcid":null,"position":4,"is_corresponding":false},{"id":1695099,"name":"YOUNG-IN YOON","orcid":null,"position":5,"is_corresponding":false},{"id":1695100,"name":"YOUNG-SUK LIM","orcid":null,"position":6,"is_corresponding":false},{"id":1695101,"name":"DAE-YOUNG JUN","orcid":null,"position":7,"is_corresponding":false},{"id":1695102,"name":"KI-HUN KIM","orcid":null,"position":8,"is_corresponding":false},{"id":1695103,"name":"GI-WON SONG","orcid":null,"position":9,"is_corresponding":false},{"id":1695104,"name":"DEOG-BOK MOON","orcid":null,"position":10,"is_corresponding":false},{"id":1695105,"name":"BAEK-YEOL RYOO","orcid":null,"position":11,"is_corresponding":false},{"id":1695106,"name":"NAYOUNG KIM","orcid":null,"position":12,"is_corresponding":false},{"id":1695107,"name":"SUNG-GYU LEE","orcid":null,"position":13,"is_corresponding":false},{"id":1695093,"name":"EUNYOUNG TAK","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Apoptosis of Hepatitis B Virus-expressing Liver Tumor Cells Induced by a High Concentration of Nucleos(t)ide Analogue","abstract":"BACKGROUND/AIM: We investigated the expression of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and HBV X protein (HBx) in human hepatocellular carcinoma (HCC) and evaluated the effect of high-concentration nucleos(t)ide analogs (NUCs) on liver tumor cell lines. MATERIALS AND METHODS: This study consisted of three parts: part I used human blood and non-tumor liver tissues; part II used human HCC and adjacent liver tissues; and part III used an HBV-expressing liver tumor cell line. RESULTS: There were close correlations among blood and liver HBV DNA and liver cccDNA. HBV cccDNA and HBx were highly up-regulated in HCC compared to adjacent liver tissues despite NUC therapy. HBV cccDNA and HBx were highly up-regulated in the cccDNA-expressing HepG2.2.15 cell line. Their expression was down-regulated and apoptosis was induced by a very high concentration of NUCs in dose- and time-dependent manner. CONCLUSION: Very high concentrations of NUCs may have a novel potential to kill replicating HBV-expressing liver tumor cells.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27793933","pmcid":null,"openalex_id":"https://openalex.org/W2546156211","authors":[],"funders":[],"total_grants":0,"fwci":0.6771,"citation_percentile":0.73839291,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://ar.iiarjournals.org/content/36/11/6059.full.pdf","host_type":"journal"},{"url":"http://ar.iiarjournals.org/content/36/11/6059.full.pdf","host_type":"publisher"},{"url":"https://doi.org/10.21873/anticanres.11195","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27793933","host_type":"repository"}],"fields_of_study":["Hepatitis B Virus Studies","DNA Repair Mechanisms","Virus-based gene therapy research","Apoptosis","Hepatitis B virus","Humans","Liver Neoplasms","Nucleosides","Nucleotides"],"mesh_terms":["Hepatitis B virus","Humans","Liver Neoplasms","Nucleosides","Nucleotides","Apoptosis"],"keywords":["cccDNA","HBx","Hepatitis B virus","Hepatocellular carcinoma","Apoptosis","Virology","Cell culture","Biology","Liver cancer","Hepatitis","Hepatitis B","Molecular biology","Cancer research","Virus","HBsAg","Transcatheter arterial chemoembolization","Entecavir","Tenofovir","Covalently Closed Circular Dna","Hbv X Protein"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:53:20.945661Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}