{"doi":"10.2174/978160805078910901010057","title":"Natural Biopolymers in Gene Therapy Delivery","abstract":"<jats:p>Effective delivery of therapeutic genes to target cells is an essential goal of all\ninnovative gene therapy endeavours and recombinant vaccine technology. Current use of viral\nvectors in achieving this goal has been associated with minimal success and plethora of\nunwanted adverse events. As a result, there is an ongoing search for suitable vector platforms\nfor the delivery of therapeutic genes to target cells. Such agent should be easily manipulated to\naccommodate small and large gene inserts and safely deliver Transgenes. This will ensure\neffective expression of the gene in target cells. The resulting optimal expression of this gene\nmay correct defective or deficient gene in individuals receiving gene therapy. This chapter\nexamines the applications of biopolymers as non-viral gene delivery vectors either alone or as\ncopolymers.</jats:p>","journal":"Biopolymers In Drug Delivery: Recent Advances and Challenges","year":2008,"id":597096,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1529505,"name":"Edward C. Nwanegbo","orcid":null,"position":1,"is_corresponding":false},{"id":1529506,"name":"Charles O. Esimone","orcid":null,"position":2,"is_corresponding":false},{"id":1529504,"name":"Chukwuemeka S. Nworu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Natural Biopolymers in Gene Therapy Delivery","abstract":"<jats:p>Effective delivery of therapeutic genes to target cells is an essential goal of all\ninnovative gene therapy endeavours and recombinant vaccine technology. Current use of viral\nvectors in achieving this goal has been associated with minimal success and plethora of\nunwanted adverse events. As a result, there is an ongoing search for suitable vector platforms\nfor the delivery of therapeutic genes to target cells. Such agent should be easily manipulated to\naccommodate small and large gene inserts and safely deliver Transgenes. This will ensure\neffective expression of the gene in target cells. The resulting optimal expression of this gene\nmay correct defective or deficient gene in individuals receiving gene therapy. This chapter\nexamines the applications of biopolymers as non-viral gene delivery vectors either alone or as\ncopolymers.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23304386","pmcid":null,"openalex_id":"https://openalex.org/W2284231492","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.13092843,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.2174/978160805078910901010057","host_type":"ebook platform"}],"fields_of_study":["RNA Interference and Gene Delivery","Virus-based gene therapy research","Viral Infectious Diseases and Gene Expression in Insects"],"mesh_terms":[],"keywords":["Genetic enhancement","Gene delivery","Viral vector","Gene","Vector (molecular biology)","Transgene","Vectors in gene therapy","Computational biology","Gene expression","Biology","Recombinant DNA","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T12:14:53.620427Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}