{"doi":"10.2174/1874609808999150831112939","title":"Age-related Decrease of Sirtuin 2 Protein in Human Peripheral Blood Mononuclear Cells","abstract":null,"journal":"Current Aging Science","year":2015,"id":677793,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":778342,"name":"Rie Karasawa","orcid":"0000-0003-3554-9194","position":1,"is_corresponding":false},{"id":1770963,"name":"Junji Ishikawa","orcid":null,"position":2,"is_corresponding":false},{"id":778343,"name":"Kazuo Yudoh","orcid":"0000-0003-0775-0181","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Age-related Decrease of Sirtuin 2 Protein in Human Peripheral Blood Mononuclear Cells","abstract":"Sirtuin 2, which is mainly present in cytoplasm, plays an important role in mammalian development, caloric restriction, metabolic regulation cellular antioxidant potential and the regulation of aging. We found that the protein level of sirtuin 2 in human peripheral blood mononuclear cells (PBMCs) decreases with an advance in donor age in men and women. Our data suggest that sirtuin 2 level in PBMCs decreases with age in both men and women and may have a potential as a useful biomarker monitoring health conditions and aging. Keywords: Age-related disease, aging, biomarker, healthy condition, peripheral blood mononuclear cells, physical activity, sirtuin 2, sirtuins.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25643068","pmcid":null,"openalex_id":"https://openalex.org/W20180091","authors":[],"funders":[],"total_grants":0,"fwci":0.6672,"citation_percentile":0.70396055,"influential_citations":0,"citation_trend":[{"year":2017,"count":3},{"year":2018,"count":1},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://eurekaselect.com/article/download/134489","host_type":"publisher"},{"url":"https://doi.org/10.2174/1874609808999150831112939","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25643068","host_type":"repository"}],"fields_of_study":["Sirtuins and Resveratrol in Medicine","Cancer, Hypoxia, and Metabolism","Lipid metabolism and disorders"],"mesh_terms":["Adult","Age Factors","Aged","Female","Humans","Leukocytes, Mononuclear","Male","Middle Aged","Sirtuin 2"],"keywords":["Peripheral blood mononuclear cell","Sirtuin 1","Sirtuin","Peripheral blood","Peripheral","Medicine","Immunology","Chemistry","Biology","Internal medicine","Biochemistry","In vitro","Enzyme","Downregulation and upregulation","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T04:33:18.398682Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}