{"doi":"10.2174/1874467209666160112123746","title":"Mevalonate Cascade and its Regulation in Cholesterol Metabolism in Different Tissues in Health and Disease","abstract":null,"journal":"Current Molecular Pharmacology","year":2017,"id":639004,"datarank":0.5837730447165941,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":0.0,"self_endowment_contribution":0.5837730447165941,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":507112,"name":"Reyhane Hoshyar","orcid":"0000-0001-7713-3897","position":1,"is_corresponding":false},{"id":1659974,"name":"Sudharsana Ande","orcid":null,"position":2,"is_corresponding":false},{"id":1659976,"name":"Qi M. Chen","orcid":null,"position":3,"is_corresponding":false},{"id":1659978,"name":"Claudia Solomon","orcid":null,"position":4,"is_corresponding":false},{"id":1659980,"name":"Anne Zuse","orcid":null,"position":5,"is_corresponding":false},{"id":1659981,"name":"Mohammad Naderi","orcid":null,"position":6,"is_corresponding":false},{"id":1659973,"name":"Mohammad Hashemi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mevalonate Cascade and its Regulation in Cholesterol Metabolism in Different Tissues in Health and Disease","abstract":"The cholesterol biosynthesis pathway, also referred to as the mevalonate (MVA) pathway, is responsible for the biosynthesis of two key isoprenoids: farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP). Post-translational modification of small GTPases by FPP and GGPP has captured much attention due to their potential contribution to cancer, cardiovascular and neurodegenerative diseases. The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) catalyzes the conversion of HMG-CoA to MVA, and is the rate-limiting step in the biosynthesis of cholesterol. Statins are HMGCR inhibitors that are used extensively in the treatment of hypercholesterolemia. Inhibitors of the MVA pathway exhibit anti-tumor effects and may reduce cancer incidence and cancer-related mortality in humans. In this review, we will focus on the mevalonate cascade and its regulation in cholesterol metabolism as well as polymorphisms of the MVA cascade in cancer development, infectious and cardiovascular disease (CVD).","is_dataset_classified":null,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26758949","pmcid":null,"openalex_id":"https://openalex.org/W2307121817","authors":[],"funders":[],"total_grants":0,"fwci":0.9621,"citation_percentile":0.76073132,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":6},{"year":2021,"count":2},{"year":2022,"count":9},{"year":2023,"count":4},{"year":2024,"count":8},{"year":2025,"count":7},{"year":2026,"count":6}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://eurekaselect.com/article/download/138464","host_type":"publisher"},{"url":"https://doi.org/10.2174/1874467209666160112123746","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26758949","host_type":"repository"}],"fields_of_study":["Plant biochemistry and biosynthesis","Cancer, Lipids, and Metabolism","Lipoproteins and Cardiovascular Health","Acyl Coenzyme A","Animals","Cardiovascular Diseases","Cholesterol","GTP Phosphohydrolases","Humans","Hydroxymethylglutaryl CoA Reductases","Hydroxymethylglutaryl-CoA Reductase Inhibitors","Infections","Mevalonic Acid","Neoplasms","Polyisoprenyl Phosphates","Sesquiterpenes","Signal Transduction"],"mesh_terms":["Acyl Coenzyme A","Animals","Cardiovascular Diseases","Cholesterol","Humans","Hydroxymethylglutaryl CoA Reductases","Infections","Mevalonic Acid","Neoplasms","Polyisoprenyl Phosphates","Sesquiterpenes","Signal Transduction","Hydroxymethylglutaryl-CoA Reductase Inhibitors","GTP Phosphohydrolases"],"keywords":["Mevalonate pathway","Geranylgeranyl pyrophosphate","Farnesyl pyrophosphate","Mevalonic acid","Cholesterol","HMG-CoA reductase","Biosynthesis","Coenzyme A","Hydroxymethylglutaryl-CoA reductase","Enzyme","Biochemistry","Biology","Pharmacology","Reductase","Internal medicine","Medicine","Statin","Rho GTPase","Mevalonate Cascade","3-Hydroxy-3- Methylglutaryl-coenzyme A."],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T22:12:02.214019Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}