{"doi":"10.2174/1874082000903020067","title":"Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines","abstract":null,"journal":"The Open Neuroscience Journal","year":2009,"id":614658,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278582,"name":"Iryna M. Ethell","orcid":"0000-0002-1324-6611","position":1,"is_corresponding":false},{"id":1583950,"name":"Crystal G. Pontrello","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines","abstract":"Dendritic spines are actin-rich structures that accommodate the postsynaptic sites of most excitatory synapses in the brain. Although dendritic spines form and mature as synaptic connections develop, they remain plastic even in the adult brain, where they can rapidly grow, change, or collapse in response to normal physiological changes in synaptic activity that underlie learning and memory. Pathological stimuli can adversely affect dendritic spine shape and number, and this is seen in neurodegenerative disorders and some forms of mental retardation and autism as well. Many of the molecular signals that control these changes in dendritic spines act through the regulation of filamentous actin (F-actin), some through direct interaction with actin, and others via downstream effectors. For example, cortactin, cofilin, and gelsolin are actin-binding proteins that directly regulate actin dynamics in dendritic spines. Activities of these proteins are precisely regulated by intracellular signaling events that control their phosphorylation state and localization. In this review, we discuss how actin-regulating proteins maintain the balance between F-actin assembly and disassembly that is needed to stabilize mature dendritic spines, and how changes in their activities may lead to rapid remodeling of dendritic spines.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20463852","pmcid":"PMC2867483","openalex_id":"https://openalex.org/W2101176534","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH067121","title":null}],"total_grants":1,"fwci":1.2727,"citation_percentile":0.75945361,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":5},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":3},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.2174/1874082000903020067","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20463852","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2867483","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Cellular Mechanics and Interactions","Advanced Fluorescence Microscopy Techniques"],"mesh_terms":[],"keywords":["Dendritic spine","Cofilin","Actin remodeling of neurons","Cortactin","Dendritic filopodia","Actin remodeling","Cell biology","Biology","Synaptic plasticity","Neuroscience","Actin","Excitatory postsynaptic potential","Postsynaptic potential","Actin cytoskeleton","Chemistry","Inhibitory postsynaptic potential","Cytoskeleton","Receptor","Biochemistry","Cell"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T15:06:53.137419Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}