{"doi":"10.2174/1874070700701010047","title":"Effects of Retinoic Acid on Proliferation and Differentiation of HepG2\nCells","abstract":"<jats:p>Hepatoma cell lines have characteristics derived from both their hepatic lineage and their transformation. We\nexamined the potential of retinoic acid to enhance the function of a hepatoma cell line, HepG2, under conditions of reduced\nserum as are desired for bioreactor cultivation. We found that retinoic acid drastically slows the growth of HepG2\ncells and induces a more spread morphology. Retinoic acid also augments the differentiated function of the cells, as measured\nby albumin and urea secretion rates. Expression levels of a panel of liver-enriched transcription factor were increased\nfrom retinoic acid exposure. Overall, we demonstrate that retinoic acid has significant effects on HepG2 growth and differentiated\nfunction. These results have implications for the use of retinoic acid both as a chemotherapeutic agent and as a\nmedium component for cells of hepatic origin.</jats:p>","journal":"The Open Biotechnology Journal","year":2007,"id":652704,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":445886,"name":"Charles M. Roth","orcid":"0000-0002-4924-0721","position":1,"is_corresponding":false},{"id":1702785,"name":"Michelle R. Burley","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of Retinoic Acid on Proliferation and Differentiation of HepG2\nCells","abstract":"<jats:p>Hepatoma cell lines have characteristics derived from both their hepatic lineage and their transformation. We\nexamined the potential of retinoic acid to enhance the function of a hepatoma cell line, HepG2, under conditions of reduced\nserum as are desired for bioreactor cultivation. We found that retinoic acid drastically slows the growth of HepG2\ncells and induces a more spread morphology. Retinoic acid also augments the differentiated function of the cells, as measured\nby albumin and urea secretion rates. Expression levels of a panel of liver-enriched transcription factor were increased\nfrom retinoic acid exposure. Overall, we demonstrate that retinoic acid has significant effects on HepG2 growth and differentiated\nfunction. These results have implications for the use of retinoic acid both as a chemotherapeutic agent and as a\nmedium component for cells of hepatic origin.</jats:p>","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19162232","pmcid":null,"openalex_id":"https://openalex.org/W2156515185","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.1250948,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2019,"count":1},{"year":2021,"count":1},{"year":2023,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://openbiotechnologyjournal.com/VOLUME/1/PAGE/47/PDF/","host_type":"journal"},{"url":"https://openbiotechnologyjournal.com/VOLUME/1/PAGE/47/PDF/","host_type":"publisher"},{"url":"https://openbiotechnologyjournal.com/contents/volumes/V1/TOBIOTJ-1-47/TOBIOTJ-1-47.pdf","host_type":"publisher"},{"url":"https://openbiotechnologyjournal.com/contents/volumes/V1/TOBIOTJ-1-47/TOBIOTJ-1-47.xml","host_type":"publisher"},{"url":"https://doi.org/10.2174/1874070700701010047","host_type":"journal"}],"fields_of_study":["Retinoids in leukemia and cellular processes","RNA Interference and Gene Delivery","Virus-based gene therapy research"],"mesh_terms":[],"keywords":["Retinoic acid","Retinoic acid-inducible orphan G protein-coupled receptor","Cell biology","Tretinoin","Retinoic acid receptor","Cell culture","Cellular differentiation","Chemistry","Retinoic acid receptor beta","Albumin","Cell growth","Retinoic acid receptor alpha","Function (biology)","Transcription factor","Biology","Biochemistry","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T16:38:53.999854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}