{"doi":"10.2174/138920012803762765","title":"Hepatic Steatosis and Peroxisomal Fatty Acid Beta-oxidation","abstract":null,"journal":"Current Drug Metabolism","year":2012,"id":608212,"datarank":0.635115975689589,"base_score":4.23410650459726,"endowment":4.23410650459726,"self_citation_contribution":0.635115975689589,"citation_network_contribution":0.0,"self_endowment_contribution":0.635115975689589,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":141728,"name":"Sailesh Surapureddi","orcid":null,"position":1,"is_corresponding":false},{"id":1561989,"name":"Hammam I. El Hajj","orcid":null,"position":2,"is_corresponding":false},{"id":1561990,"name":"Joseph Vamecq","orcid":null,"position":3,"is_corresponding":false},{"id":1561991,"name":"Pierre Andreoletti","orcid":null,"position":4,"is_corresponding":false},{"id":1561988,"name":"Mustapha Cherkaoui-Malki","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hepatic Steatosis and Peroxisomal Fatty Acid Beta-oxidation","abstract":"Three subhepatocellular compartments concur for fatty acids degradation including ω-oxidation in endoplasmic reticulum and β-oxidation in both mitochondria and peroxisomes. Deficits affecting the peroxisomal physiology may be associated with multiple metabolic disturbances. Nowadays, a growing body of evidence underlines the key role of peroxisomal β-oxidation in the sensing of lipid metabolism through the production/degradation of some essential metabolites. Lessons from several mice models strengthen the link between fatty acid β-oxidation in peroxisomes and the nuclear hormone receptor Peroxisome Proliferator-Activated Receptor (PPAR)-α with an additional level of coregualtor complexity, which couples regulation of body energetic balance and hepatic caloric flux to functional peroxisome status. Here, we review key determinants of disrupted peroxisomal β-oxidation pathway, which in liver promotes hepatic steatosis and hepatocarcinogenesis.","is_dataset_classified":null,"base_score":4.23410650459726,"endowment":4.23410650459726,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22978396","pmcid":null,"openalex_id":"https://openalex.org/W2099798070","authors":[],"funders":[{"funder_name":"Intramural NIH HHS","grant_id":"","title":null}],"total_grants":1,"fwci":1.8406,"citation_percentile":0.85238033,"influential_citations":0,"citation_trend":[{"year":2013,"count":6},{"year":2014,"count":4},{"year":2015,"count":5},{"year":2016,"count":9},{"year":2017,"count":3},{"year":2018,"count":4},{"year":2019,"count":5},{"year":2020,"count":6},{"year":2021,"count":6},{"year":2022,"count":5},{"year":2023,"count":5},{"year":2024,"count":6},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://eurekaselect.com/article/download/104215","host_type":"publisher"},{"url":"https://doi.org/10.2174/138920012803762765","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22978396","host_type":"repository"}],"fields_of_study":["Peroxisome Proliferator-Activated Receptors","Liver Disease Diagnosis and Treatment","Adipose Tissue and Metabolism"],"mesh_terms":["Animals","Fatty Acids","Fatty Liver","Humans","Liver Neoplasms","Oxidation-Reduction","Peroxisomes","PPAR alpha"],"keywords":["Peroxisome","Beta oxidation","Steatosis","Peroxisome proliferator-activated receptor alpha","Biochemistry","Endoplasmic reticulum","Lipid metabolism","Flux (metallurgy)","Biology","Chemistry","Endocrinology","Internal medicine","Fatty acid","Nuclear receptor","Cell biology","Receptor","Medicine","Transcription factor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:43:12.051405Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}