{"doi":"10.2174/1381612033454720","title":"Potential Drug Targets on the HIV-1 Envelope Glycoproteins, gp120 and gp41","abstract":null,"journal":"Current Pharmaceutical Design","year":2003,"id":655684,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":247089,"name":"Linda Zhang","orcid":"0000-0001-9486-419X","position":1,"is_corresponding":false},{"id":1711619,"name":"Chin Chen","orcid":null,"position":2,"is_corresponding":false},{"id":706623,"name":"Li Huang","orcid":"0000-0003-2146-2119","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Potential Drug Targets on the HIV-1 Envelope Glycoproteins, gp120 and gp41","abstract":"HIV-1 entry is an attractive target for anti-HIV-1 therapy. However, there are no entry inhibitors approved for the clinical treatment of HIV-1 infection. This is likely to be changed in the near future since promising HIV-1 entry inhibitors, such as T20 and some chemokine receptor antagonists, are in the pipeline to join the repertoire of anti-HIV-1 therapeutics. This review will focus on what might be potential targets on the key components of the viral entry machinery, gp120 and gp41. These two molecules are the viral proteins responsible for HIV-1 entry. Binding to CD4 induces a series of structural changes in gp120 and allows it to interact with chemokine receptors. The receptor binding eventually triggers conformational changes in gp41, which result in the formation of a fusion active molecule to attack the cell membrane. The structural and functional motifs that operate this delicate fusion machinery could become the Achilles' heel of the virus.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12769725","pmcid":null,"openalex_id":"https://openalex.org/W2151991598","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI49096","title":null}],"total_grants":1,"fwci":0.2931,"citation_percentile":0.48692153,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2014,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://eurekaselect.com/article/download/63893","host_type":"publisher"},{"url":"https://doi.org/10.2174/1381612033454720","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12769725","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV/AIDS drug development and treatment","Monoclonal and Polyclonal Antibodies Research","HIV Envelope Protein gp120","HIV Envelope Protein gp41","HIV Infections","HIV-1","Humans","Virus Replication"],"mesh_terms":["Humans","Virus Replication","HIV-1","HIV Infections","HIV Envelope Protein gp120","HIV Envelope Protein gp41"],"keywords":["Gp41","Lipid bilayer fusion","Viral entry","Entry inhibitor","Glycoprotein","Chemokine receptor","Viral envelope","Cell biology","Human immunodeficiency virus (HIV)","Receptor","Chemokine","Chemokine receptor CCR5","Drug","Biology","Chemistry","Virology","Computational biology","Virus","Immunology","Biochemistry","Antibody","Viral replication","Pharmacology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T18:34:50.809471Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}