{"doi":"10.2174/092986606775974401","title":"Comparative Study of Apoptosis Induced by H2O2 and NO: Limitation of Apoptosis Induced by NO Due to Slower Recovery of Activity of NOModified Caspase","abstract":null,"journal":"Protein & Peptide Letters","year":2006,"id":634166,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":506682,"name":"Heeyoung Seok","orcid":"0000-0003-2699-9935","position":1,"is_corresponding":false},{"id":414574,"name":"Pratap Karki","orcid":"0000-0002-3087-5516","position":2,"is_corresponding":false},{"id":620365,"name":"Jung Lee","orcid":"0000-0003-1177-7117","position":3,"is_corresponding":false},{"id":1644613,"name":"Song Shin","orcid":null,"position":4,"is_corresponding":false},{"id":1644614,"name":"Byungyun Cho","orcid":null,"position":5,"is_corresponding":false},{"id":217140,"name":"Il-Seon Park","orcid":"0000-0003-4754-6142","position":6,"is_corresponding":false},{"id":203469,"name":"Ja-Eun Kim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparative Study of Apoptosis Induced by H2O2 and NO: Limitation of Apoptosis Induced by NO Due to Slower Recovery of Activity of NOModified Caspase","abstract":"Both H(2)O(2) and NO can act as apoptogens, triggering apoptosis in many cells. They are also well known inhibitors of caspases, essential enzymes in apoptosis. The differences between these two agents as apoptosis inducers and how caspases mediate apoptosis with these inhibitory agents is still unclear. Consistent with the previous reports, these two agents induced apoptosis accompanied by caspase activation with limitation of all apoptotic events for NO. It was found that NO-modified caspase-3 showed a slower recovery of its activity in the presence of the reducing agents compared to that of H(2)O(2) modification. This is one possible cause of the limited apoptosis in the case of NO.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16712518","pmcid":null,"openalex_id":"https://openalex.org/W2152442751","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.11832554,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://eurekaselect.com/article/download/56934","host_type":"publisher"},{"url":"https://doi.org/10.2174/092986606775974401","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16712518","host_type":"repository"}],"fields_of_study":["Redox biology and oxidative stress","Free Radicals and Antioxidants"],"mesh_terms":["Enzyme Activation","Humans","Hydrogen Peroxide","Nitric Oxide","Apoptosis","Jurkat Cells","Caspases","Cytochromes c","Caspase 3","Caspase Inhibitors"],"keywords":["Apoptosis","Caspase 3","Caspase","Biology","Cell biology","Chemistry","Programmed cell death","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:16:30.026217Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}