{"doi":"10.2172/1901591","title":"Maturation of <em>Rhodobacter capsulatus</em> Multicopper Oxidase CutO Depends on the CopA Copper Efflux Pathway and Requires the <em>cutF</em> Product (Final Report)","abstract":"The goal is to achieve a comprehensive understanding of the nature, mechanism of function and biogenesis of c-type cytochromes and their oligomeric complexes. These cytochrome are ubiquitous heme proteins that are required for cellular bioenergetics, including photosynthesis (Ps) and respiration (Res), which are central to chemical energy (ATP) production by oxidative- and photophosphorylation. We contribute to the molecular characterization of individual and membrane-integral cytochromes as parts of Ps and Res electron transport (ET) pathways, using the facultative phototrophic bacteria of as excellent models for multidisciplinary investigations. Supported by this grant we discovered novel membrane-bound cytochromes and cyts c complexes that are important for Ps- and Res-ET. We worked out their biogenesis including maturation (covalent heme addition) and assembly of mature subunits into complexes. These involve fundamental process found virtually in all organisms and are fundamental processes with major significance to the “Photosynthetic Systems” program of DOE-BES, because the cytochromes are integral components of natural energy production systems. Elucidation of basic principles, and the knowledge gained by their study greatly impact on our ability to design, engineer, and create new natural, bio-hybrid, bio-inspired and artificial systems to better capture light, transduce and store its energy with improved efficacy and are of broad significance.","journal":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","year":2021,"id":231221,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":325524,"name":"Crysten E. Blaby‐Haas","orcid":"0000-0002-1583-1291","position":1,"is_corresponding":false},{"id":752692,"name":"Noel Daum","orcid":null,"position":2,"is_corresponding":false},{"id":260893,"name":"Andreea Andrei","orcid":null,"position":3,"is_corresponding":false},{"id":260894,"name":"Juna Rauch","orcid":null,"position":4,"is_corresponding":false},{"id":257796,"name":"Fevzi Daldal","orcid":"0000-0002-2865-9574","position":5,"is_corresponding":false},{"id":257797,"name":"Hans‐Georg Koch","orcid":"0000-0001-5913-0334","position":6,"is_corresponding":false},{"id":257794,"name":"Yavuz Öztürk","orcid":"0000-0002-9650-6350","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:55:12.400773Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}