{"doi":"10.21518/ms2024-267","title":"The effect of cholecalciferol subsidies on the level of pro-inflammatory cytokines in children with bronchial asthma","abstract":"<jats:p><jats:bold>Introduction.</jats:bold> Currently, there are insufficient studies to demonstrate the effect of vitamin D status on the production of proinflammatory cytokines in children with allergic diseases, which precipitated this study.</jats:p><jats:p><jats:bold>Aim. </jats:bold>To analyse interferon<jats:sub>-</jats:sub><jats:sub>γ</jats:sub>, interleukin-17A and 33 profiles in children with asthma according to serum calcidiol levels before and during cholecalciferol subsidies.</jats:p><jats:p><jats:bold>Materials and methods. </jats:bold>A total of 71 children aged 3 to 18 years were examined: 51 patients with asthma and 20 children in the control group. A 3-month cholecalciferol course at a prophylactic dose specified in the national program was prescribed to all children. 25(OH)D, interferon-<jats:sub>γ</jats:sub>, interleukin-17A and 33 levels were twice determined in the examined children.</jats:p><jats:p><jats:bold>Results and discussion. </jats:bold>Median 25(OH)D levels in patients with asthma did not reach the levels of healthy children either before or after cholecalciferol subsidies at prophylactic doses. Vitamin D intake led to a decrease in interferon-<jats:sub>γ</jats:sub> levels in healthy children from 3.07 [2.29; 4.81] pg/ml to 2.18 [1.74; 3.45] pg/ml (p &lt; 0.05). In patients with asthma, such changes were not detected in the initial population, however, after cholecalciferol subsidies their interferon-<jats:sub>γ</jats:sub> levels were significantly higher than those in healthy children: 3.11 [0.89; 5.0] pg/ml and 2.18 [1.74; 3.45] pg/ml, respectively (p &lt; 0.05). Assessment results of interleukin-17A levels in children with asthma showed that the median cytokine levels were significantly higher before the cholecalciferol subsidies than after them: 2.03 [0.1; 10.01] pg/ml and 0.96 [0.1; 12.87] pg/ml, respectively (p = 0.03). The median interleukin-17A levels in children with asthma were significantly higher than in healthy children, both before and during the cholecalciferol subsidies. The median interleukin-33 levels were significantly higher in children with asthma as compared to healthy children, both before and during vitamin D subsidies.</jats:p><jats:p><jats:bold>Conclusion.</jats:bold> Our results suggest that cholecalciferol has a modulatory effect on interferon-<jats:sub>γ</jats:sub> and interleukin-17A in patients with asthma. Interleukin-33 levels did not change significantly in children with asthma on cholecalciferol.</jats:p>","journal":"Meditsinskiy sovet = Medical Council","year":2024,"id":612952,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1578666,"name":"A. A. Tolkunova","orcid":"0000-0001-6983-0967","position":1,"is_corresponding":false},{"id":1578667,"name":"I. N. Zakharova","orcid":"0000-0003-4200-4598","position":2,"is_corresponding":false},{"id":1578668,"name":"V. R. Ponamaryova","orcid":"0009-0007-9505-3349","position":3,"is_corresponding":false},{"id":1578669,"name":"L. Ya. Klimov","orcid":"0000-0001-7248-1614","position":4,"is_corresponding":false},{"id":1578670,"name":"L. Yu. Barycheva","orcid":"0000-0002-4069-0566","position":5,"is_corresponding":false},{"id":1578671,"name":"N. V. Zaritovskaya","orcid":"0009-0009-9178-1634","position":6,"is_corresponding":false},{"id":1578672,"name":"V. V. Kuznetsova","orcid":"0009-0003-5246-0527","position":7,"is_corresponding":false},{"id":1578673,"name":"E. A. Enina","orcid":"0000-0002-5306-8223","position":8,"is_corresponding":false},{"id":1578665,"name":"S. V. Dolbnya","orcid":"0000-0002-2056-153X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The effect of cholecalciferol subsidies on the level of pro-inflammatory cytokines in children with bronchial asthma","abstract":"<jats:p><jats:bold>Introduction.</jats:bold> Currently, there are insufficient studies to demonstrate the effect of vitamin D status on the production of proinflammatory cytokines in children with allergic diseases, which precipitated this study.</jats:p><jats:p><jats:bold>Aim. </jats:bold>To analyse interferon<jats:sub>-</jats:sub><jats:sub>γ</jats:sub>, interleukin-17A and 33 profiles in children with asthma according to serum calcidiol levels before and during cholecalciferol subsidies.</jats:p><jats:p><jats:bold>Materials and methods. </jats:bold>A total of 71 children aged 3 to 18 years were examined: 51 patients with asthma and 20 children in the control group. A 3-month cholecalciferol course at a prophylactic dose specified in the national program was prescribed to all children. 25(OH)D, interferon-<jats:sub>γ</jats:sub>, interleukin-17A and 33 levels were twice determined in the examined children.</jats:p><jats:p><jats:bold>Results and discussion. </jats:bold>Median 25(OH)D levels in patients with asthma did not reach the levels of healthy children either before or after cholecalciferol subsidies at prophylactic doses. Vitamin D intake led to a decrease in interferon-<jats:sub>γ</jats:sub> levels in healthy children from 3.07 [2.29; 4.81] pg/ml to 2.18 [1.74; 3.45] pg/ml (p &lt; 0.05). In patients with asthma, such changes were not detected in the initial population, however, after cholecalciferol subsidies their interferon-<jats:sub>γ</jats:sub> levels were significantly higher than those in healthy children: 3.11 [0.89; 5.0] pg/ml and 2.18 [1.74; 3.45] pg/ml, respectively (p &lt; 0.05). Assessment results of interleukin-17A levels in children with asthma showed that the median cytokine levels were significantly higher before the cholecalciferol subsidies than after them: 2.03 [0.1; 10.01] pg/ml and 0.96 [0.1; 12.87] pg/ml, respectively (p = 0.03). The median interleukin-17A levels in children with asthma were significantly higher than in healthy children, both before and during the cholecalciferol subsidies. The median interleukin-33 levels were significantly higher in children with asthma as compared to healthy children, both before and during vitamin D subsidies.</jats:p><jats:p><jats:bold>Conclusion.</jats:bold> Our results suggest that cholecalciferol has a modulatory effect on interferon-<jats:sub>γ</jats:sub> and interleukin-17A in patients with asthma. Interleukin-33 levels did not change significantly in children with asthma on cholecalciferol.</jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W4401545734","authors":[],"funders":[],"total_grants":0,"fwci":0.2681,"citation_percentile":0.58217704,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.med-sovet.pro/jour/article/download/8436/7413","host_type":"journal"},{"url":"https://www.med-sovet.pro/jour/article/download/8436/7413","host_type":"publisher"},{"url":"https://www.med-sovet.pro/jour/article/viewFile/8436/7413","host_type":"publisher"},{"url":"https://doi.org/10.21518/ms2024-267","host_type":"journal"}],"fields_of_study":["Asthma and respiratory diseases","IL-33, ST2, and ILC Pathways","Human Health and Disease"],"mesh_terms":[],"keywords":["Cholecalciferol","Asthma","Subsidy","Medicine","Vitamin D and neurology","Internal medicine","Immunology","Economics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T05:48:04.128939Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}