{"doi":"10.2147/ppa.s226619","title":"&lt;p&gt;Associations Between Health Literacy and Medication Self-Management Among Community Health Center Patients with Uncontrolled Hypertension&lt;/p&gt;","abstract":"PURPOSE: Examine associations between health literacy and several medication self-management constructs among a population of adults with uncontrolled hypertension. PATIENTS AND METHODS: Cross-sectional study of health center patients from the Chicago area with uncontrolled hypertension enrolled between April 2012 and February 2015. Medication self-management constructs-applied to hypertension medications, chronic condition medications and all medications-included: 1) medication reconciliation, 2) knowledge of drug indications, 3) understanding instructions and dosing, and 4) self-reported adherence over 4 days (no missed doses). We determined associations between health literacy and self-management outcomes using multivariable generalized linear regression. RESULTS: There were 1460 patients who completed screening interviews; 62.9% enrolled and had complete baseline data collected, and were included in the analysis. Of 919 participants, 47.4% had likely limited (low), 33.2% possibly limited, and 19.4% likely adequate health literacy. Compared to participants with likely adequate health literacy, participants with low health literacy were less likely to have chronic medications reconciled (18.0% versus 29.6%, p=0.007), know indications for chronic medications (64.1% versus 83.1%, p<0.001), and demonstrate understanding of instructions and dosing (68.1% versus 82.9%, p=0.001). Self-reported adherence to hypertension medications was higher among the low health literacy group (65.6% versus 56.0%, p=0.010). In multivariable models, health literacy was strongly associated with knowledge of drug indications, and understanding of instructions and dosing. CONCLUSION: Low health literacy was associated with worse medication self-management in several domains. However, non-adherence was greatest in the most health literate in unadjusted analysis. Among a population of patients with uncontrolled hypertension, the drivers of poor control may vary by health literacy.","journal":"Patient Preference and Adherence","year":2020,"id":62378,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9099,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":330467,"name":"Kunal N. Karmali","orcid":null,"position":1,"is_corresponding":false},{"id":329611,"name":"Ji Young Lee","orcid":"0000-0002-6102-0510","position":2,"is_corresponding":false},{"id":329612,"name":"Danielle Lazar","orcid":"0000-0002-1480-8436","position":3,"is_corresponding":false},{"id":330468,"name":"Tiffany Brown","orcid":null,"position":4,"is_corresponding":false},{"id":329613,"name":"Elisha M. Friesema","orcid":"0000-0002-4186-9242","position":5,"is_corresponding":false},{"id":110278,"name":"Michael S. Wolf","orcid":"0000-0002-4342-6517","position":6,"is_corresponding":false},{"id":110292,"name":"Stephen D. Persell","orcid":"0000-0003-2462-1314","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T21:10:11.612909Z","pmid":"32021120","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}