{"doi":"10.2147/ppa.s224496","title":"&lt;p&gt;Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents&lt;/p&gt;","abstract":"Purpose: There are growing concerns about patients’ adherence to oral anticancer agents (OAAs), and the need for patients to engage in self-management of OAA-related side effects. We assessed associations among adherence, severity of side effects, and effectiveness of self-management of side effects in patients taking capecitabine. Methods: Adherence to capecitabine at 6 weeks was measured by the Medication Event Monitoring System among 50 patients with gastrointestinal cancers. Severity of side effects related to capecitabine and effectiveness of self-management of side effects were captured using the Modified Self-Care Diary at the time of enrollment and weekly for 6 weeks. Spearman’s correlation, Mann–Whitney U -tests, and multiple linear regression were conducted, p <0.05. Results: Overall mean adherence rate was 85.4±14.1%. Adherence rate was not significantly correlated to the mean severity of total side effects at any time point and was correlated with the mean effectiveness of self-management of total side effects only at week 2 ( rho =0.29, p =0.04). However, adherence rate was associated with the mean severity of one specific side effect, diarrhea, at 6 weeks ( rho =0.36, p =0.01) and marginally correlated to the mean effectiveness of self-management of diarrhea at 6 weeks ( rho =0.28, p =0.05). Mean severity of diarrhea at 6 weeks was an independent predictor of adherence rate ( b =4.97, p =0.01), with the control of age ( b =0.52, p =0.002), number of outpatient medications ( b =1.12, p =0.007), health literacy ( b =2.53, p =0.04), diagnosis of colorectal cancer ( b =11.6, p =0.03), and capecitabine in combination with other chemotherapies ( b =16.8, p =0.001) in the model. Conclusion: This pilot study suggests ongoing examination of both severity and effectiveness of self-management of side effects in future studies of adherence to OAAs is merited. There is a need for future studies with larger sample sizes that explore the complex relationships among adherence, severity of side effects, and effectiveness of self-management of side effects in OAA therapy. Keywords: oral anticancer agents, adherence, side effects, self-management","journal":"Patient Preference and Adherence","year":2020,"id":69561,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9622,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":368644,"name":"Karen E. Wickersham","orcid":"0000-0003-0214-4596","position":1,"is_corresponding":false},{"id":370158,"name":"Xingyu Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":368645,"name":"Debra L. Barton","orcid":"0000-0001-6624-3476","position":3,"is_corresponding":false},{"id":368646,"name":"Karen B. Farris","orcid":"0000-0002-5636-3009","position":4,"is_corresponding":false},{"id":368647,"name":"John C. Krauss","orcid":"0000-0002-5197-736X","position":5,"is_corresponding":false},{"id":368648,"name":"Marcelline R. Harris","orcid":"0000-0002-3957-6643","position":6,"is_corresponding":false},{"id":370157,"name":"Yun Jiang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T21:42:48.813846Z","pmid":"32099335","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}