{"doi":"10.2147/por.s251120","title":"<p>The CHRONICLE Study of US Adults with Subspecialist-Treated Severe Asthma: Objectives, Design, and Initial Results</p>","abstract":"Background: Approximately 5– 10% of patients with asthma have severe disease. High-quality real-world studies are needed to identify areas for improved management. Objective: Aligned with the International Severe Asthma Registry, the CHRONICLE study (ClinicalTrials.gov: NCT03373045) was developed to address this need in the US. Study Design: Learnings from prior studies were applied to develop a real-world, prospective, noninterventional study of US patients with confirmed severe asthma who are treated by subspecialist physicians and require biologic or maintenance systemic immunosuppressant therapy or who are uncontrolled by high-dosage inhaled corticosteroids and additional controllers. Target enrollment is 4000 patients, with patient observation for ≥ 3 years. A geographically diverse sample of allergist/immunologist and pulmonologist sites approach all eligible patients under their care and report patient characteristics, treatment, and health outcomes every 6 months. Patients complete online surveys every 1– 6 months. Initial Results: From February 2018 to February 2019, 102 sites screened 1428 eligible patients; 936 patients enrolled. Study sites (40% allergist/immunologist, 42% pulmonologist, 18% both) were similar to other US asthma subspecialist samples. Enrolled patients were 67% female with median ages at enrollment and diagnosis of 55 (range: 18– 89) and 26 (0– 80) years, respectively. Median body mass index was 31 kg/m 2 ; 3% and 29% were current or former smokers, respectively, and > 60% reported ≥ 1 exacerbation in the prior year and suboptimal symptom control. Conclusion: CHRONICLE will provide high-quality provider- and patient-reported data from a large, real-world cohort of US adults with subspecialist-treated severe asthma. Keywords: asthma exacerbations, longitudinal studies, allergists, pulmonologists, biologic therapy","journal":"Pragmatic and Observational Research","year":2020,"id":103270,"datarank":0.9550837457880359,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.46636926508481347,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.46636926508481347,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":11,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6988,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03373045"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":503234,"name":"Bradley E. Chipps","orcid":"0009-0000-7857-9225","position":1,"is_corresponding":false},{"id":286634,"name":"Wendy C. Moore","orcid":"0000-0001-6869-3059","position":2,"is_corresponding":false},{"id":503235,"name":"Weily Soong","orcid":"0000-0002-2701-7035","position":3,"is_corresponding":false},{"id":228868,"name":"Jennifer Trevor","orcid":"0000-0001-6072-6274","position":4,"is_corresponding":false},{"id":502548,"name":"Dennis K. Ledford","orcid":"0000-0003-2541-7075","position":5,"is_corresponding":false},{"id":504030,"name":"Warner W. Carr","orcid":null,"position":6,"is_corresponding":false},{"id":109637,"name":"Njira Lugogo","orcid":"0000-0002-0235-7105","position":7,"is_corresponding":false},{"id":504031,"name":"Frank Trudo","orcid":null,"position":8,"is_corresponding":false},{"id":503236,"name":"Trung N. Tran","orcid":"0000-0001-8003-7601","position":9,"is_corresponding":false},{"id":247084,"name":"Reynold A. Panettieri","orcid":"0000-0003-0834-4636","position":10,"is_corresponding":false},{"id":503233,"name":"Christopher S. Ambrose","orcid":"0000-0003-4175-7336","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T22:42:17.920911Z","pmid":"32765156","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}