{"doi":"10.2147/plmi.s447545","title":"Serum Lipids, Insulin-Like Growth Factor Binding Protein-3 and Treatment Outcomes in Women with and without Cervical Lesions in South Western Uganda: A Cohort Study","abstract":"Purpose: There is a documented association between cervical cancer and metabolic syndrome. In this study, we determined the association between lipids, insulin-like growth factor binding protein-3 (IGFBP-3) and treatment outcomes for cervical lesions at Mbarara Regional Referral Hospital (MRRH) in south western Uganda. Patients and Methods: In this prospective cohort study, we recruited 94 cases and 94 controls at the cervical cancer clinic of MRRH, and followed them for 12 months. Cases were confirmed with cytology and/or histology. With consent, we collected demographic data and measured lipids and IGFBP-3 both at baseline and after 12 months. The lipid profile was measured using a Cobas 6000 Chemistry Analyzer, whereas IGFBP-3 was measured using a MAGLUMI fully automated chemiluminescence immunoassay analyzer. Abnormal values for lipids were defined using WHO recommended cut-offs. IGFBP-3 concentrations were divided into two categories of low concentration (< 3.29 μg/mL) and raised concentration (≥ 3.29 μg/mL). Statistical analyses were conducted in STATA version 17 using logistic regression analysis. A p -value of < 0.05 was taken to be statistically significant. Results: The average (mean ± SD) age of our participants was 38.7± 8.2 years for controls and 34.5± 7.8 years for cases. The average serum IGFBP-3 concentration was 3.769± 1.098 μg/mL among cases with cleared lesions and 3.505± 0.979 μg/mL among cases whose lesions persisted. A serum IGFBP-3 concentration of less than 3.291 μg/mL was likely to be associated with clearance of cervical lesions (AOR 1.65, p =0.67), although this was not statistically significant. A serum triglyceride concentration of 35– 135 mg/dL was also likely to be associated with clearance of cervical lesions (AOR 2.41, p =0.46), although this was also not statistically significant. Conclusion: Although not statistically significant, reduced serum concentrations of IGFBP-3 and triglyceride may be associated with clearance of cervical lesions. Lipid management may be of benefit in the treatment of cervical lesions. Keywords: cervical intraepithelial neoplasia, cervical lesions, clearance, persistence, IGFBP-3","journal":"Pathology and Laboratory Medicine International","year":2023,"id":379449,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8229,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":285992,"name":"Thomas C. Randall","orcid":"0000-0002-3230-0310","position":1,"is_corresponding":false},{"id":1085872,"name":"Deusdedit Tusubira","orcid":"0000-0002-4698-424X","position":2,"is_corresponding":false},{"id":789066,"name":"Cesar M. Castro","orcid":"0000-0002-1159-5658","position":3,"is_corresponding":false},{"id":475722,"name":"Josephine Nambi Najjuma","orcid":"0000-0001-5894-5961","position":4,"is_corresponding":false},{"id":1143848,"name":"Christopher Okeny","orcid":"0009-0002-8865-4537","position":5,"is_corresponding":false},{"id":1143849,"name":"Doreen Nuwashaba","orcid":"0009-0005-3183-9727","position":6,"is_corresponding":false},{"id":1143850,"name":"Hope Mudondo","orcid":"0009-0008-7273-4341","position":7,"is_corresponding":false},{"id":1085871,"name":"Rogers Kajabwangu","orcid":"0000-0003-4101-011X","position":8,"is_corresponding":false},{"id":1144223,"name":"Joy Muhumuza","orcid":null,"position":9,"is_corresponding":false},{"id":732821,"name":"Alexcer Namuli","orcid":"0009-0009-4185-4479","position":10,"is_corresponding":false},{"id":484676,"name":"Joseph Ngonzi","orcid":"0000-0001-5253-9516","position":11,"is_corresponding":false},{"id":1085870,"name":"Frank Ssedyabane","orcid":"0000-0002-6836-5749","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-19T01:16:52.622552Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}