{"doi":"10.2147/opth.s356631","title":"A Pilot Study of Subclinical Non-Capillary Peripapillary Perfusion Changes in Thyroid-Related Orbitopathy Detected Using Optical Coherence Tomography Angiography","abstract":"Purpose: Hemodynamic changes surrounding the optic nerve head are known to occur in thyroid-related orbitopathy (TRO). This pilot study explores the capillary and non-capillary peripapillary perfusion changes of the retina in TRO eyes without dysthyroid optic neuropathy (DON) using optical coherence tomography angiography (OCT-A). Methods: Non-capillary and capillary peripapillary perfusion densities were calculated using single 4.5 × 4.5mm en face \"RPC layer\" OCT-A scans of 8 TRO patients without DON (8 eyes, mean age 40.6 years, range 23-69 years). Results were compared to a previously published dataset of 133 healthy controls (133 eyes, mean 41.5 years, range 11-83 years). The strength of association was measured between OCT-A perfusion densities and clinical measures of TRO. Results: Non-capillary peripapillary perfusion density in TRO eyes was found to be significantly decreased compared to healthy controls (TRO group 15.4 ± 2.9% vs controls 21.5 ± 3.1%; p < 0.0001). Capillary peripapillary perfusion densities showed no significant difference (TRO group 42.5 ± 1.8% vs controls 42.5 ± 1.5%; p = 1.0). Clinical measures of disease did not correlate well with OCT-A perfusion densities (p>0.05). Conclusion: These findings may represent decreased blood flow and subclinical ischemia to the optic nerve. We discuss possible pathogenic mechanisms of thyroid-related vasculopathy, including vessel wall thickening due to immunologically-induced media enlargement.","journal":"Clinical ophthalmology","year":2022,"id":272540,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8993,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":939570,"name":"Jorge S Andrade Romo","orcid":null,"position":1,"is_corresponding":false},{"id":389553,"name":"Giselle Lynch","orcid":null,"position":2,"is_corresponding":false},{"id":388552,"name":"Davis B. Zhou","orcid":"0000-0001-5712-4408","position":3,"is_corresponding":false},{"id":388556,"name":"Maria V. Castanos","orcid":"0000-0002-4257-5369","position":4,"is_corresponding":false},{"id":939571,"name":"Phillip A Tenzel","orcid":null,"position":5,"is_corresponding":false},{"id":428067,"name":"Oscar Otero-Marquez","orcid":"0000-0003-1591-9952","position":6,"is_corresponding":false},{"id":939572,"name":"Shoshana Yakubova","orcid":null,"position":7,"is_corresponding":false},{"id":939573,"name":"Alexander Barash","orcid":null,"position":8,"is_corresponding":false},{"id":939574,"name":"David Della Rocca","orcid":null,"position":9,"is_corresponding":false},{"id":939575,"name":"Robert Della Rocca","orcid":null,"position":10,"is_corresponding":false},{"id":939576,"name":"Toco YP Chui","orcid":null,"position":11,"is_corresponding":false},{"id":939577,"name":"Richard B Rosen","orcid":null,"position":12,"is_corresponding":false},{"id":939578,"name":"Harsha S Reddy","orcid":null,"position":13,"is_corresponding":false},{"id":746396,"name":"Alexander Pinhas","orcid":"0000-0003-1708-5840","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T00:27:47.926496Z","pmid":"35340669","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}