{"doi":"10.2147/ndt.s514514","title":"Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric Disorders","abstract":null,"journal":"Neuropsychiatric Disease and Treatment","year":2025,"id":621917,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1606226,"name":"Bernhard Baune","orcid":null,"position":1,"is_corresponding":false},{"id":351441,"name":"Alessandro Serretti","orcid":"0000-0003-4363-3759","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric Disorders","abstract":"Schizophrenia polygenic risk scores (SCZ PRS) have emerged as important tools for modulating factors not only in schizophrenia but also in major psychiatric disorders, such as major depression (MDD) and bipolar disorder (BD). Initially developed to capture the common variant risk for SCZ, accumulating evidence highlights the transdiagnostic impact of SCZ PRS on clinical severity, treatment response, and functional outcomes. This review synthesizes recent findings on the relationship between SCZ PRS and treatment outcomes across SCZ, BD, and MDD. A higher SCZ PRS is associated with poorer treatment outcomes, including treatment resistance or non-remission to antidepressants in MDD, reduced antipsychotic response in SCZ, and diminished lithium efficacy in BD. SCZ PRS is also linked to persistent negative symptoms, cognitive impairments, and long-term illness severity in SCZ. While the effect sizes are generally modest, integration of SCZ PRS with environmental factors, multiomics, and neuroimaging may enhance predictive accuracy. Despite variability in reported associations, the overarching evidence supports a transdiagnostic influence of SCZ PRS on disease trajectories and treatment responses. As a promising component of precision psychiatry, SCZ PRS holds potential for guiding more targeted and effective interventions. Future research should focus on combining SCZ PRS with multimodal approaches to fully realize its clinical utility.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40098640","pmcid":"PMC11912901","openalex_id":"https://openalex.org/W4408387462","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"101057454","title":"Psych-STRATA - A Stratified Treatment Algorithm in Psychiatry: A program on stratified pharmacogenomics in severe mental illness"}],"total_grants":1,"fwci":7.562,"citation_percentile":0.97383278,"influential_citations":0,"citation_trend":[{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.dovepress.com/article/download/101107","host_type":"journal"},{"url":"https://www.dovepress.com/article/download/101107","host_type":"publisher"},{"url":"https://doi.org/10.2147/ndt.s514514","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40098640","host_type":"repository"},{"url":"https://www.dovepress.com/transdiagnostic-effects-of-schizophrenia-polygenic-scores-on-treatment-peer-reviewed-fulltext-article-NDT","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11912901","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11912901","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11912901?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.2147/NDT.S514514","host_type":""},{"url":"http://dx.doi.org/10.2147/ndt.s514514","host_type":""}],"fields_of_study":["Genetic Associations and Epidemiology","Schizophrenia research and treatment","Mental Health Research Topics"],"mesh_terms":[],"keywords":["Medicine","Schizophrenia (object-oriented programming)","Psychiatry","Polygenic risk score","Genetics","Gene","Single-nucleotide polymorphism","Genotype","Schizophrenia","Bipolar disorder","Treatment Outcomes","Major Depressive Disorder","Polygenic Risk Scores","Precision Psychiatry","Neuropsychiatric Disease and Treatment","Review"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T16:51:11.896129Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}