{"doi":"10.2147/ndt.s235395","title":"<p>APOE ϵ4 Allele Is Associated with Elevated Levels of CSF VILIP-1 in Preclinical Alzheimer’s Disease</p>","abstract":"OBJECTIVES: Cerebrospinal fluid (CSF) visinin-like protein 1 (VILIP-1) has been suggested as a biomarker for neuron injury, which has been shown to have a important diagnostic value in symptomatic Alzheimer's disease (AD). The study purpose is investigating potential effects of apolipoprotein E (APOE) ε4 on CSF VILIP-1 levels among the preclinical AD. METHODS: A total of 110 subjects (including 43 APOE ε4 carriers and 67 ε4 non-carriers) were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) in the present study. RESULTS: The results showed that VILIP-1 concentrations in the CSF were statistically significantly increased in APOE ε4 carriers in comparison with non-carriers. Increased CSF VILIP-1 level was positively associated with the concentrations of both CSF-tau and P-tau levels. CONCLUSIONS: Our findings suggested that APOE ε4 might affect CSF VILIP-1 level in preclinical AD, indicating an important role of APOE ε4 in neuron injury leading to AD.","journal":"Neuropsychiatric Disease and Treatment","year":2020,"id":89888,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8043,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":453579,"name":"Miao Zhang","orcid":"0000-0003-4912-2570","position":1,"is_corresponding":false},{"id":453580,"name":"Qian Wang","orcid":"0000-0002-1201-865X","position":2,"is_corresponding":false},{"id":453581,"name":"Xianguo Jiang","orcid":"0000-0002-3636-7336","position":3,"is_corresponding":false},{"id":453582,"name":"Kunyi Li","orcid":"0000-0002-8520-7064","position":4,"is_corresponding":false},{"id":453583,"name":"Jun Liu","orcid":"0000-0001-9202-5878","position":5,"is_corresponding":false},{"id":453578,"name":"Lijun Wang","orcid":"0000-0001-6145-1997","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T22:02:27.195966Z","pmid":"32308396","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}