{"doi":"10.2147/ndt.s210658","title":"<p>Resting-state functional magnetic resonance imaging (fMRI) and functional connectivity density mapping in patients with corneal ulcer</p>","abstract":null,"journal":"Neuropsychiatric Disease and Treatment","year":2019,"id":672172,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1756153,"name":"Liying Tang","orcid":null,"position":1,"is_corresponding":false},{"id":1756154,"name":"Peiwen Zhu","orcid":"0000-0002-6361-2923","position":2,"is_corresponding":false},{"id":84963,"name":"Qi Lin","orcid":"0000-0001-5026-1100","position":3,"is_corresponding":false},{"id":480790,"name":"Qing Yuan","orcid":"0000-0001-9851-0284","position":4,"is_corresponding":false},{"id":762841,"name":"Wenqing Shi","orcid":"0000-0002-9153-5865","position":5,"is_corresponding":false},{"id":406800,"name":"Biao Li","orcid":"0000-0002-0493-2062","position":6,"is_corresponding":false},{"id":865907,"name":"Lei Ye","orcid":"0000-0002-6529-6178","position":7,"is_corresponding":false},{"id":1756155,"name":"Youlan Min","orcid":null,"position":8,"is_corresponding":false},{"id":1126461,"name":"Ting Su","orcid":"0000-0001-6292-1209","position":9,"is_corresponding":false},{"id":648318,"name":"Yi Shao","orcid":"0000-0002-3237-8310","position":10,"is_corresponding":false},{"id":1756152,"name":"Feiying Zhu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"<p>Resting-state functional magnetic resonance imaging (fMRI) and functional connectivity density mapping in patients with corneal ulcer</p>","abstract":"PURPOSE: To investigate alternations in spontaneous brain activities reflected by functional connectivity density (FCD) in patients with corneal ulcer (CU) using resting-state functional connectivity (rsFC). METHODS: We recruited 24 patients with CU (12 males, 12 females), and 24 healthy controls (HCs; 12 males, 12 females) matched for age, gender and education status. Functional magnetic resonance imaging examinations were performed on all subjects in a resting state and the following parameters determined: rsFC, long-range FCD (longFCD) and short-range FCD (IFCD). Receiver operating characteristic (ROC) curves were then used to differentiate patients with CU from HCs. RESULTS: Compared with HCs, CU patients showed significantly reduced rsFC values in the right cerebellum posterior lobe gyrus, right middle frontal gyrus/inferior frontal gyrus/superior frontal gyrus and left inferior parietal lobule/precuneus. Significantly reduced longFCD values were found in the right hippocampus/inferior temporal gyrus and the left inferior temporal gyrus. Moreover, compared with HCs, IFCD values were significantly reduced in the left inferior temporal gyrus/middle temporal gyrus, left limbic lobe/medial frontal gyrus, and left precuneus/limbic lobe, but were significantly increased in the right insula/superior temporal gyrus, left superior temporal gyrus/inferior frontal gyrus/insula, right superior temporal gyrus/postcentral gyrus, and left precentral gyrus. CONCLUSIONS: Patients with CU exhibited alterations in spontaneous brain activities in several brain areas. These novel findings may help to reveal the neuropathological mechanisms underlying CU. This study provides a direction for further exploration of underlying neural mechanisms of CU and facilitate the clinical diagnosis and treatment of CU.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31308676","pmcid":"PMC6617566","openalex_id":"https://openalex.org/W2955841648","authors":[],"funders":[],"total_grants":0,"fwci":2.1137,"citation_percentile":0.86605277,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":2}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.dovepress.com/getfile.php?fileID=51001","host_type":"journal"},{"url":"https://www.dovepress.com/getfile.php?fileID=51001","host_type":"publisher"},{"url":"https://doi.org/10.2147/ndt.s210658","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31308676","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6617566","host_type":"repository"},{"url":"https://www.dovepress.com/resting-state-functional-magnetic-resonance-imaging-fmri-and-functiona-peer-reviewed-article-NDT","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6617566","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6617566?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Ocular Surface and Contact Lens","Ocular Diseases and Behçet’s Syndrome","Ophthalmology and Visual Impairment Studies"],"mesh_terms":[],"keywords":["Precuneus","Superior frontal gyrus","Limbic lobe","Medicine","Medial frontal gyrus","Inferior frontal gyrus","Middle temporal gyrus","Inferior temporal gyrus","Superior temporal gyrus","Postcentral gyrus","Functional magnetic resonance imaging","Middle frontal gyrus","Neuroscience","Lingual gyrus","Resting state fMRI","Temporal lobe","Insula","Gyrus","Anatomy","Psychology","Radiology","Psychiatry","Corneal Ulcer","Functional Connectivity Density","Spontaneous Brain Activities"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Quality Education"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T07:41:08.249430Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}