{"doi":"10.2147/jpr.s597049","title":"Personalized Multimodal and Opioid-Sparing Analgesia for Postoperative Pain Management: Enhancing Recovery and Addressing the Post-Discharge Gap","abstract":null,"journal":"Journal of Pain Research","year":2026,"id":634601,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1645950,"name":"Emery Niyonkuru","orcid":"0009-0004-6267-6783","position":1,"is_corresponding":false},{"id":1645947,"name":"Marie Louise Sezerano","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Personalized Multimodal and Opioid-Sparing Analgesia for Postoperative Pain Management: Enhancing Recovery and Addressing the Post-Discharge Gap","abstract":"Postoperative pain remains a persistent clinical challenge affecting more than 80% of surgical patients, driving prolonged hospitalization, delayed recovery, and progression to chronic postsurgical pain. Opioid-centered analgesia, despite its historical primacy, is constrained by dependence, tolerance, opioid-induced hyperalgesia, and a critical post-discharge prescribing gap in which prescribed quantities consistently exceed actual patient consumption, perpetuating avoidable harm without proportional improvement in outcomes. Enhanced Recovery After Surgery protocols emphasize multimodal, opioid-sparing strategies combining pharmacologic agents including NSAIDs, acetaminophen, gabapentinoids, ketamine, dexmedetomidine, and intravenous lidocaine with neuraxial and peripheral nerve blocks and non-pharmacologic interventions including cognitive-behavioral therapy, physical rehabilitation, acupuncture, and digital therapeutics. Current evidence identifies NSAIDs combined with dexamethasone or regional anesthesia as delivering the greatest opioid-sparing efficacy, while emerging precision-based approaches incorporating pharmacogenomic-guided prescribing, machine learning-based pain prediction, and wearable monitoring platforms offer transformative opportunities for individualized perioperative analgesic optimization. Significant gaps persist including heterogeneity in multimodal regimen combinations, inconsistent outcome measures, limited post-discharge standardization, and insufficient long-term data on chronic postsurgical pain prevention and functional recovery across diverse surgical populations. Future research must prioritize procedure-specific, standardized, and pharmacogenomically informed multimodal protocols integrating technological innovations to optimize recovery, minimize opioid-related risks, and ensure sustainable, patient-centered perioperative pain management.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42017149","pmcid":null,"openalex_id":"https://openalex.org/W7154511043","authors":[],"funders":[],"total_grants":0,"fwci":33.0902,"citation_percentile":0.99745593,"influential_citations":1,"citation_trend":[{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.dovepress.com/article/download/114130","host_type":"journal"},{"url":"https://www.dovepress.com/article/download/114130","host_type":"GOLD"},{"url":"https://www.dovepress.com/article/download/114130","host_type":"publisher"},{"url":"https://doi.org/10.2147/jpr.s597049","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42017149","host_type":"repository"},{"url":"https://www.dovepress.com/personalized-multimodal-and-opioid-sparing-analgesia-for-postoperative-peer-reviewed-fulltext-article-JPR","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13094574/","host_type":"repository"}],"fields_of_study":["Pain Management and Opioid Use","Anesthesia and Pain Management","Opioid Use Disorder Treatment","Medicine"],"mesh_terms":[],"keywords":["Postoperative pain","Multimodal therapy","MEDLINE","Pain management","Pharmacogenomics","Multimodal Analgesia","Regional Anesthesia","Chronic Postsurgical Pain","Enhanced Recovery After Surgery","Opioid Sparing","Perioperative Pain Management","Opioids Exposure"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:53:33.025306Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}