{"doi":"10.2147/jhc.s452564","title":"Plasma Growth Hormone as a Prognostic Biomarker to Durvalumab and Tremelimumab in Patients with Advanced Hepatocellular Carcinoma","abstract":"Introduction: In this study, we explored the potential of plasma growth hormone (GH) as a prognostic biomarker in patients with advanced HCC treated with durvalumab plus tremelimumab (D+T). Methods: In this study, we included 16 patients with advanced HCC who received D+T at MD Anderson Cancer Center between 2022 and 2023 and had plasma GH measurements recorded before treatment. Plasma GH levels were measured from prospectively collected blood samples and were correlated with progression-free survival (PFS) and overall survival (OS). The cutoff for normal GH levels in women and men was defined as ≤3.7 μg/L and ≤0.9 μg/L, respectively. The Kaplan-Meier method was employed to compute the median OS and PFS, while the Log rank test was applied to compare the survival outcomes between the GH-high and GH-low groups. Results: Sixteen patients were included in this analysis, two female and fourteen male, with a median age of 65.5 years. At the time of the analysis, the 6-month OS rate was 100% among GH-low patients (6 patients) and 30% among GH-high patients (10 patients). OS was significantly longer in GH-low patients (not evaluable) compared to GH-high patients (3.94 months) (p = 0.030). PFS was also significantly longer in GH-low patients (not evaluable) compared to the GH-high patients (1.87 months) (p = 0.036). Conclusion: Plasma GH is a prognostic biomarker in patients with advanced HCC treated with D+T. Given the relatively small patient cohort size, this finding should be further validated in larger randomized clinical trials in advanced HCC patients.","journal":"Journal of Hepatocellular Carcinoma","year":2024,"id":470602,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8222,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1066022,"name":"Michael LaPelusa","orcid":"0000-0001-6078-0561","position":1,"is_corresponding":false},{"id":419794,"name":"Lianchun Xiao","orcid":"0000-0003-0972-2766","position":2,"is_corresponding":false},{"id":573501,"name":"Yehia I. Mohamed","orcid":"0000-0002-5192-3804","position":3,"is_corresponding":false},{"id":485050,"name":"Sunyoung Lee","orcid":"0000-0002-6893-3136","position":4,"is_corresponding":false},{"id":1305358,"name":"Zishuo Hu","orcid":null,"position":5,"is_corresponding":false},{"id":573503,"name":"Rikita Hatia","orcid":"0000-0003-2591-5963","position":6,"is_corresponding":false},{"id":420932,"name":"Manal M. Hassan","orcid":"0000-0002-8413-449X","position":7,"is_corresponding":false},{"id":368861,"name":"James C. Yao","orcid":"0000-0002-1875-3962","position":8,"is_corresponding":false},{"id":238100,"name":"Dan G. Duda","orcid":"0000-0001-7065-8797","position":9,"is_corresponding":false},{"id":722040,"name":"Saumil Datar","orcid":"0000-0002-0772-2108","position":10,"is_corresponding":false},{"id":473838,"name":"Hesham M. Amin","orcid":"0000-0002-7973-6699","position":11,"is_corresponding":false},{"id":54196,"name":"Ahmed O. Kaseb","orcid":"0000-0002-9491-0587","position":12,"is_corresponding":false},{"id":911594,"name":"Shadi Chamseddine","orcid":"0000-0001-7715-0689","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T02:05:40.740958Z","pmid":"38463542","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}