{"doi":"10.2147/jaa.s227732","title":"&lt;p&gt;Exhaled Nitric Oxide in Wheezy Infants Predicts Persistent Atopic Asthma and Exacerbations at School Age&lt;/p&gt;","abstract":"Background: There are limited data assessing the predictive value of fraction of exhaled nitric oxide (FE NO ) in infants/toddlers with recurrent wheezing for asthma at school age. Objectives: In a cohort of infants/toddlers with recurrent wheezing determine the predictive values of sedated single-breath FE NO (SB-FE NO ) and awake tidal-breathing mixed-expired FE NO (tidal-FE NO ) for active asthma, severe exacerbations, and lung function at age 6 years. Methods: In 44 infants/toddlers, SB-FE NO was measured under sedation at 50 mL/sec in conjunction with forced expiratory flow and volume measurements, and tidal-FE NO was measured during awake tidal breathing. Clinical outcomes and lung function were assessed at age 6 years in 36 subjects. Results: Enrollment SB-FE NO was significantly higher among subjects with active asthma at age 6 years than among subjects without asthma (36.4 vs. 16.9 ppb, p < 0.0001), and the odds of asthma was 7.6 times greater (OR 7.6; 95% CI 1.8–31.6) for every 10 ppb increase in enrollment SB-FE NO . A ROC analysis demonstrated that an enrollment SB-FE NO > 31.5 ppb predicted active asthma at age 6 years with an area under the curve (AUC) of 0.92 (95% CI: 0.82–1). SB-FE NO was also higher among subjects who experienced severe asthma exacerbations during the year preceding age of 6 years. SB-FE NO at enrollment and lung function measures at age 6 years were modestly correlated (FEV1: r = −0.4; FEF25-75: r = −0.41; FEV1/FVC ratio: r=−0.46), and SB-FE NO was significantly higher among subjects with bronchodilator responsiveness (BDR) at age 6 years. Tidal-FE NO was not predictive of active asthma, exacerbations, or lung function at age 6 years. Conclusion: In wheezy infants/toddlers, SB-FE NO was predictive of school-age asthma and associated with lung function measures at age 6 years. Keywords: exhaled nitric oxide, FE NO , recurrent wheezing, infants, asthma, pulmonary function, exacerbations","journal":"Journal of Asthma and Allergy","year":2020,"id":85134,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9632,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":435885,"name":"Tessa K. Kolstad","orcid":"0000-0002-0506-4797","position":1,"is_corresponding":false},{"id":436896,"name":"Molly Elliott","orcid":null,"position":2,"is_corresponding":false},{"id":435886,"name":"Elizabeth S. Cochrane","orcid":"0000-0002-1648-4754","position":3,"is_corresponding":false},{"id":435887,"name":"David Stamey","orcid":"0000-0003-3013-1522","position":4,"is_corresponding":false},{"id":239696,"name":"Jason S. Debley","orcid":"0000-0001-6438-9535","position":5,"is_corresponding":false},{"id":436895,"name":"Maria P. White","orcid":null,"position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T21:56:02.794896Z","pmid":"32021309","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}