{"doi":"10.2147/idr.s405256","title":"Thirty-Day Outcomes of Young and Middle-Aged Adults Admitted with Severe COVID-19 in Uganda: A Retrospective Cohort Study","abstract":"Background: There is scarcity of data regarding young and middle-aged adults hospitalized with severe Corona Virus Disease 2019 (COVID-19) in Africa. In this study, we describe the clinical characteristics and 30-day survival among adults aged 18 to 49 years admitted with severe COVID-19 in Uganda. Methods: We reviewed treatment records of patients admitted with severe COVID-19 across five COVID-19 treatment units (CTU) in Uganda. We included individuals aged 18 to 49 years, who had a positive test or met the clinical criteria for COVID-19. We defined severe COVID-19 as having an oxygen saturation <94%, lung infiltrates >50% on imaging and presence of a co-morbidity that required admission in the CTU. Our main outcome was the 30-day survival from the time of admission. We used a Cox proportional hazards model to determine the factors associated with 30-day survival at a 5% level of significance. Results: Of the 246 patient files reviewed, 50.8% (n = 125) were male, the mean ± (standard deviation) age was 39 ± 8 years, majority presented with cough, 85.8% (n = 211) and median C-reactive protein (interquartile range) was 48 (47.5, 178.8) mg/L. The 30-day mortality was 23.9% (59/246). At admission, anemia (hazard ratio (HR): 3.00, 95% confidence interval (CI), 1.32-6.82; p = 0.009) and altered mental state (GCS <15) (HR: 6.89, 95% CI: 1.48-32.08, p = 0.014) were significant predictors of 30-day mortality. Conclusion: There was a high 30-day mortality among young and middle-aged adults with severe COVID-19 in Uganda. Early recognition and targeted management of anemia and altered consciousness are needed to improve clinical outcomes.","journal":"Infection and Drug Resistance","year":2023,"id":388250,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5317,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":698527,"name":"Timothy Mwanje Kintu","orcid":"0000-0002-5513-5899","position":1,"is_corresponding":false},{"id":1157477,"name":"Emmanuel Miiro","orcid":"0000-0001-5039-9900","position":2,"is_corresponding":false},{"id":1157821,"name":"Franchesca Nabalamba","orcid":null,"position":3,"is_corresponding":false},{"id":1157822,"name":"Gloria Suubi Asiimwe","orcid":null,"position":4,"is_corresponding":false},{"id":1157823,"name":"Anne Marion Namutebi","orcid":null,"position":5,"is_corresponding":false},{"id":1157824,"name":"Fardous Charles Abeya","orcid":null,"position":6,"is_corresponding":false},{"id":824788,"name":"Boniface Amanee Elias Lumori","orcid":"0000-0002-8697-8979","position":7,"is_corresponding":false},{"id":1157825,"name":"Isaac Ijuka","orcid":null,"position":8,"is_corresponding":false},{"id":333896,"name":"Rose Muhindo","orcid":"0000-0001-7128-4870","position":9,"is_corresponding":false},{"id":1157478,"name":"Andrew Mutekanga","orcid":"0000-0003-3780-2202","position":10,"is_corresponding":false},{"id":1157479,"name":"Richard Musinguzi","orcid":"0000-0002-0323-1862","position":11,"is_corresponding":false},{"id":1157826,"name":"Francis Natuhwera","orcid":null,"position":12,"is_corresponding":false},{"id":484676,"name":"Joseph Ngonzi","orcid":"0000-0001-5253-9516","position":13,"is_corresponding":false},{"id":292463,"name":"Edwin Nuwagira","orcid":"0000-0001-7526-9504","position":14,"is_corresponding":false},{"id":698528,"name":"Tonny Kyagambiddwa","orcid":"0000-0003-4411-2672","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T01:18:13.977537Z","pmid":"37197696","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}