{"doi":"10.2147/copd.s322144","title":"Association of Systemic Inflammation with Depressive Symptoms in Individuals with COPD","abstract":"Rationale: Depression is a prevalent comorbidity of chronic obstructive pulmonary disease (COPD) that, along with COPD, has been associated with inflammation. An association between inflammation and depression in COPD has not been validated in a large COPD cohort. Methods: Individuals from the University of Pittsburgh SCCOR cohort and the COPDGene cohort with tobacco use history and airway obstruction (FEV 1 /FVC < 0.7) were evaluated using the Beck Depression Inventory II (BDI-II) and the Hospital Anxiety and Depression Scale (HADS), respectively. Participants completed symptom-related questionnaires and plasma IL-6 measurements. T -test, Fisher’s Exact tests and logistic regression were used for statistical analysis. Results: The SCCOR cohort included 220 obstructed participants: 44% female and 21.4% with elevated depressive symptoms. GOLD staging distribution was predominantly stage I and II. The COPDGene cohort included 745 obstructed participants: 44% female and 13.0% with elevated depressive symptoms. GOLD distribution was predominantly stage II and III. In the SCCOR cohort, correlation between IL-6 and depressive symptoms trended toward significance (p= 0.08). Multivariable modeling adjusted for FEV 1 , age, gender and medical comorbidities showed a significant association (OR = 1.70, 95% CI = 1.08– 2.69). IL-6 was significantly associated with elevated depressive symptoms in COPDGene in both univariate (p=0.001) and multivariable modeling (OR = 1.52, 95% CI =1.13– 2.04). Conclusion: Elevated plasma IL-6 levels are associated with depressive symptoms in individuals with COPD independent of airflow limitation and comorbid risk factors for depression. Our results suggest that systemic inflammation may play a significant and possibly bidirectional role in depression associated with COPD. Keywords: IL-6, depression, beck depression inventory, BDI, HADS, TNF-a, CRP, SCCOR, COPDGene","journal":"International Journal of COPD","year":2021,"id":168782,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270743,"name":"Mehdi Nouraie","orcid":"0000-0001-7465-0581","position":1,"is_corresponding":false},{"id":24973,"name":"Karin F. Hoth","orcid":"0000-0002-4261-5308","position":2,"is_corresponding":false},{"id":698868,"name":"Craig Riley","orcid":null,"position":3,"is_corresponding":false},{"id":698869,"name":"Chad Karoleski","orcid":null,"position":4,"is_corresponding":false},{"id":288811,"name":"Yingze Zhang","orcid":"0000-0001-6947-2901","position":5,"is_corresponding":false},{"id":326871,"name":"Nicola A. Hanania","orcid":"0000-0003-3087-9530","position":6,"is_corresponding":false},{"id":24947,"name":"Russell P. Bowler","orcid":"0000-0003-4651-363X","position":7,"is_corresponding":false},{"id":390627,"name":"Jessica Bon","orcid":"0000-0002-4336-3835","position":8,"is_corresponding":false},{"id":25014,"name":"Frank C. Sciurba","orcid":"0000-0001-7468-2225","position":9,"is_corresponding":false},{"id":698377,"name":"H. Strollo","orcid":"0000-0002-4978-7815","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T23:46:06.853307Z","pmid":"34511896","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}