{"doi":"10.2147/chc.s57679","title":"Novel perspectives on the origins of the hepatic myofibroblasts","abstract":null,"journal":"Cell Health and Cytoskeleton","year":2015,"id":613917,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":976581,"name":"Jun Xu","orcid":"0000-0002-2309-990X","position":1,"is_corresponding":false},{"id":412054,"name":"Xiao Liu","orcid":"0000-0002-1159-9667","position":2,"is_corresponding":false},{"id":812865,"name":"David Brenner","orcid":null,"position":3,"is_corresponding":false},{"id":226038,"name":"Tatiana Kisseleva","orcid":"0000-0001-9107-2306","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Novel perspectives on the origins of the hepatic myofibroblasts","abstract":"Abstract: Liver fibrosis results from chronic liver injury that causes hepatocellular damage. Damaged hepatocytes apoptose, and release factors that facilitate recruitment of leukocytes to the site of injury, which in turn mediate recruitment and activation of liver- resident (Kupffer cells) and bone marrow (BM)-derived macrophages. Activated macrophages secrete TGF-ß1, the major profibrogenic cytokine, which activates hepatic myofibroblasts, which are not present in the liver under physiological conditions. Several sources of myofibroblasts have been identified, but it is believed that liver-resident hepatic stellate cells (HSCs) and portal fibroblasts (PFs) are the major source of hepatic myofibroblasts in fibrotic liver. Fibrocytes, designated as BM-derived collagen Type I producing cells, were also implicated in liver fibrosis; hence, their contribution to liver fibrosis remains controversial. Upon removal of the etiological agent, myofibroblasts either undergo apoptosis or inactivate into a quiescent-like state, followed by resorbtion of the fibrous scar. However, prolonged/repeated liver injury triggers irreversible cross-linking of collagen fibers that prevents fibrous scar from collagenase-mediated degradation. This review will discuss several types of fibrogenic cells contributing to the myofibroblast population, and the signaling pathways regulating their activation and collagen deposition. Keywords: Liver fibrosis, TGF-ß1 signaling, hepatic stellate cells, portal fibroblasts, fibrocytes, collagen Type I deposition","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W2028408947","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"1U01AA022614-01A1","title":"The Role of IL-17 in Alcoholic Liver Disease and Cancer"},{"funder_name":"National Institutes of Health","grant_id":"3P50AA011999-12S1","title":"Southern California Research Center for ALPD and Cirrhosis"}],"total_grants":2,"fwci":0.4414,"citation_percentile":0.61859038,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.dovepress.com/getfile.php?fileID=24232","host_type":"journal"},{"url":"https://www.dovepress.com/getfile.php?fileID=24232","host_type":"publisher"},{"url":"https://doi.org/10.2147/chc.s57679","host_type":"journal"},{"url":"https://dx.doi.org/10.2147/chc.s57679","host_type":""}],"fields_of_study":["Liver physiology and pathology","Liver Disease Diagnosis and Treatment","Macrophage Migration Inhibitory Factor","0301 basic medicine","03 medical and health sciences"],"mesh_terms":[],"keywords":["Myofibroblast","Hepatic stellate cell","Fibrocyte","Fibrosis","Pathology","Cirrhosis","Liver injury","Hepatic fibrosis","Cancer research","Cell biology","Medicine","Chemistry","Biology","Endocrinology","Internal medicine"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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