{"doi":"10.2147/ceg.s404009","title":"PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease","abstract":"Background: Prostate-specific membrane antigen (PSMA) is highly and specifically upregulated in active-inflamed mucosa of patients with inflammatory bowel disease (IBD). We hypothesized that this upregulation would be detectable using a PSMA-targeted positron emission tomography/computed tomography (PET/CT) imaging agent, [ 18 F]DCFPyL, enabling non-invasive visualization of inflammation. A noninvasive means of detecting active inflammation would have high clinical value in localization and management of IBD. Study: We performed [ 18 F]DCFPyL imaging in three IBD patients with active disease. Abnormally increased gastrointestinal [ 18 F]DCFPyL uptake was observed in areas with endoscopic, histologic, and immunohistochemical inflammation, demonstrating partial overlap of segments of bowel with abnormal [ 18 F]DCFPyL uptake and active inflammation. Conclusion: This study demonstrates that PSMA-targeted [ 18 F]DCFPyL PET can effectively detect regions of inflamed mucosa in patients with IBD, suggesting its utility as a non-invasive imaging agent to assess location, extent, and disease activity in IBD. Keywords: IBD, disease activity, PSMA, GCPII, [ 18 F]DCFPyL","journal":"Clinical and Experimental Gastroenterology","year":2023,"id":371905,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1053124,"name":"Diane E. Peters","orcid":"0000-0003-4185-6203","position":1,"is_corresponding":false},{"id":267038,"name":"Steven P. Rowe","orcid":"0000-0003-2897-4694","position":2,"is_corresponding":false},{"id":1131947,"name":"Ali Salavati","orcid":"0000-0002-1909-6175","position":3,"is_corresponding":false},{"id":1131948,"name":"Sowmya Sharma","orcid":"0000-0002-3803-1537","position":4,"is_corresponding":false},{"id":59442,"name":"Robert A. Anders","orcid":"0000-0002-2363-9072","position":5,"is_corresponding":false},{"id":7932,"name":"Martin G. Pomper","orcid":"0000-0001-6753-3010","position":6,"is_corresponding":false},{"id":228373,"name":"Barbara S. Slusher","orcid":"0000-0001-9814-4157","position":7,"is_corresponding":false},{"id":270206,"name":"Florin M. Selaru","orcid":"0000-0001-7990-8238","position":8,"is_corresponding":false},{"id":1131946,"name":"Mohamed Saleh Ismail","orcid":"0000-0002-7431-7356","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T01:15:49.453761Z","pmid":"38090679","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}