{"doi":"10.2147/ceg.s306626","title":"Diagnostic Value of 14C Urea Breath Test for Helicobacter pylori Detection Compared by Histopathology in Indonesian Dyspeptic Patients","abstract":"Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as 14 C Urea Breath Test (UBT), is more favorable; however, this particular method has not been validated yet. Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and 14 C-UBT test. We used Heliprobe ® UBT for UBT test. As for the histology, May-Giemsa staining of two gastric biopsies (from the antrum and corpus) were evaluated following the Updated Sydney System. Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861– 1.000). By applying the optimum cut-off value, Heliprobe ® UBT showed 92.31% for sensitivity, 97.62% for specificity, 92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy. Conclusion: The 14 C-UBT is an accurate test for H. pylori diagnosis with excellent sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that a validation is absolutely necessary for new test prior application to the new population. Keywords: Helicobacter pylori , UBT, diagnostic, infectious disease","journal":"Clinical and Experimental Gastroenterology","year":2021,"id":202510,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6963,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":783186,"name":"Adinta Windia","orcid":null,"position":1,"is_corresponding":false},{"id":312522,"name":"Ari Fahrial Syam","orcid":"0000-0003-0041-3553","position":2,"is_corresponding":false},{"id":321736,"name":"Iswan Abbas Nusi","orcid":null,"position":3,"is_corresponding":false},{"id":782586,"name":"Ricky Indra Alfaray","orcid":"0000-0001-7721-9455","position":4,"is_corresponding":false},{"id":312520,"name":"Kartika Afrida Fauzia","orcid":"0000-0001-6901-3270","position":5,"is_corresponding":false},{"id":783187,"name":"Hartono Kahar","orcid":null,"position":6,"is_corresponding":false},{"id":783188,"name":"Herry Purbayu","orcid":null,"position":7,"is_corresponding":false},{"id":473579,"name":"Titong Sugihartono","orcid":"0000-0003-4923-9832","position":8,"is_corresponding":false},{"id":321737,"name":"Poernomo Boedi Setiawan","orcid":null,"position":9,"is_corresponding":false},{"id":473578,"name":"Ummi Maimunah","orcid":"0000-0002-2496-4336","position":10,"is_corresponding":false},{"id":782587,"name":"Ulfa Kholili","orcid":"0000-0003-3870-2051","position":11,"is_corresponding":false},{"id":782588,"name":"Husin Thamrin","orcid":"0000-0002-6176-1765","position":12,"is_corresponding":false},{"id":782589,"name":"Amie Vidyani","orcid":"0009-0006-2855-7072","position":13,"is_corresponding":false},{"id":312524,"name":"Dalla Doohan","orcid":"0000-0003-3076-571X","position":14,"is_corresponding":false},{"id":312523,"name":"Langgeng Agung Waskito","orcid":"0000-0002-9400-1973","position":15,"is_corresponding":false},{"id":312525,"name":"Yudith Annisa Ayu Rezkitha","orcid":"0000-0001-7600-9114","position":16,"is_corresponding":false},{"id":741695,"name":"Gontar Alamsyah Siregar","orcid":null,"position":17,"is_corresponding":false},{"id":312531,"name":"Yoshio Yamaoka","orcid":"0000-0002-1222-5819","position":18,"is_corresponding":false},{"id":312521,"name":"Muhammad Miftahussurur","orcid":"0000-0003-1415-6033","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T23:51:10.291262Z","pmid":"34163206","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}