{"doi":"10.2142/biophysico.12.0_103","title":"Case study on the evolution of hetero-oligomer interfaces based on the differences in paralogous proteins","abstract":null,"journal":"Biophysics and Physicobiology","year":2015,"id":603493,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":183278,"name":"Kei Yura","orcid":null,"position":1,"is_corresponding":false},{"id":1548106,"name":"Saki Aoto","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Case study on the evolution of hetero-oligomer interfaces based on the differences in paralogous proteins","abstract":"We addressed the evolutionary trace of hetero-oligomer interfaces by comparing the structures of paralogous proteins; one of them is a monomer or homo-oligomer and the other is a hetero-oligomer. We found different trends in amino acid conservation pattern and hydrophobicity between homo-oligomer and hetero-oligomer. The degree of amino acid conservation in the interface of homo-oligomer has no obvious difference from that in the surface, whereas the degree of conservation is much higher in the interface of hetero-oligomer. The interface of homo-oligomer has a few very conserved residue positions, whereas the residue conservation in the interface of hetero-oligomer tends to be higher. In addition, the interface of hetero-oligomer has a tendency of being more hydrophobic compared with the one in homo-oligomer. We conjecture that these differences are related to the inherent symmetry in homo-oligomers that cannot exist in hetero-oligomers. Paucity of the structural data precludes statistical tests of these tendencies, yet the trend can be applied to the prediction of the interface of hetero-oligomer. We obtained putative interfaces of the subunits in CPSF (cleavage and polyadenylation specificity factor), one of the human pre-mRNA 3'-processing complexes. The locations of predicted interface residues were consistent with the known experimental data.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27493859","pmcid":"PMC4736837","openalex_id":"https://openalex.org/W2292512574","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.10159597,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2021,"count":2},{"year":2022,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/biophysico/12/0/12_103/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/biophysico/12/0/12_103/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.2142/biophysico.12.0_103","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27493859","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4736837","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4736837","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4736837?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["RNA Research and Splicing","RNA and protein synthesis mechanisms","Protein Structure and Dynamics"],"mesh_terms":[],"keywords":["Oligomer","Monomer","Materials science","Chemistry","Biophysics","Polymer chemistry","Biology","Polymer","Organic chemistry","Sequence Conservation","Subunit Interface","Paralogues","Cpsf","Kyte And Doolittle Parameter"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T22:05:01.992856Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}