{"doi":"10.21417/mc2021nc","title":"Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival","abstract":"Small-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor heterogeneity (ITH) associated with high recurrence rate and suboptimal response to immunotherapy.Here, using multiregion whole exome/T cell receptor (TCR) sequencing as well as immunohistochemistry (IHC), we revealed a rather homogeneous mutational landscape but extremely cold and heterogeneous TCR repertoire in limited-stage SCLC (LS-SCLC) tumors.Compared to localized non-small cell lung cancers (NSCLCs), LS-SCLCs had similar predicted neoantigen burden and genomic ITH, but signi cantly colder and more heterogeneous TCR repertoire associated with higher chromosomal copy number aberration (CNA) burden.Higher mutational burden, higher T cell in ltration and positive PD-L1 expression were associated with longer overall survival (OS), while higher CNA burden were associated with shorter OS in patients with LS-SCLC.","journal":"immuneACCESS","year":2021,"id":229376,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9439,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":327736,"name":"R Chen","orcid":null,"position":1,"is_corresponding":false},{"id":834209,"name":"Yu-Shuang Jin","orcid":"0009-0003-7945-1487","position":2,"is_corresponding":false},{"id":195079,"name":"J Li","orcid":null,"position":3,"is_corresponding":false},{"id":136611,"name":"J Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":834398,"name":"J Fujimoto","orcid":null,"position":5,"is_corresponding":false},{"id":834210,"name":"Wan Luan Lee","orcid":"0009-0007-2156-2765","position":6,"is_corresponding":false},{"id":834399,"name":"X Hu","orcid":null,"position":7,"is_corresponding":false},{"id":834400,"name":"SM Hubert","orcid":null,"position":8,"is_corresponding":false},{"id":834401,"name":"B Zhu","orcid":null,"position":9,"is_corresponding":false},{"id":834211,"name":"Yahui Tian","orcid":"0009-0006-2004-554X","position":10,"is_corresponding":false},{"id":834402,"name":"J George","orcid":null,"position":11,"is_corresponding":false},{"id":545107,"name":"Y Chen","orcid":null,"position":13,"is_corresponding":false},{"id":834212,"name":"Mengting Wu","orcid":"0000-0002-7111-8028","position":14,"is_corresponding":false},{"id":834403,"name":"C Behrens","orcid":null,"position":15,"is_corresponding":false},{"id":834404,"name":"C Chow","orcid":null,"position":16,"is_corresponding":false},{"id":834405,"name":"HHN Pham","orcid":null,"position":17,"is_corresponding":false},{"id":834406,"name":"J Fukuoka","orcid":null,"position":18,"is_corresponding":false},{"id":834407,"name":"Jianchen Wu","orcid":null,"position":19,"is_corresponding":false},{"id":834408,"name":"ER Parra","orcid":null,"position":20,"is_corresponding":false},{"id":834409,"name":"CM Gay","orcid":null,"position":21,"is_corresponding":false},{"id":834410,"name":"LD Little","orcid":null,"position":22,"is_corresponding":false},{"id":834411,"name":"C Gumbs","orcid":null,"position":23,"is_corresponding":false},{"id":834412,"name":"Xiaofei Song","orcid":null,"position":24,"is_corresponding":false},{"id":834413,"name":"L Diao","orcid":null,"position":25,"is_corresponding":false},{"id":201761,"name":"Q Wang","orcid":null,"position":26,"is_corresponding":false},{"id":834414,"name":"R Cardnell","orcid":null,"position":27,"is_corresponding":false},{"id":114745,"name":"J Wang","orcid":null,"position":29,"is_corresponding":false},{"id":834415,"name":"DL Gibbons","orcid":null,"position":30,"is_corresponding":false},{"id":834416,"name":"JV Heymach","orcid":null,"position":31,"is_corresponding":false},{"id":834417,"name":"JJ Lee","orcid":null,"position":32,"is_corresponding":false},{"id":834418,"name":"WN William","orcid":null,"position":33,"is_corresponding":false},{"id":834419,"name":"B Glisson","orcid":null,"position":34,"is_corresponding":false},{"id":834420,"name":"I Wistuba","orcid":null,"position":35,"is_corresponding":false},{"id":834421,"name":"PA Futreal","orcid":null,"position":36,"is_corresponding":false},{"id":834422,"name":"R. 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